組蛋白 (Histone H3) 介紹
染色質結構的調節(jié)在真核生物的轉錄調控中起著重要作用。核小體是染色質的主要組成部分，由DNA 纏繞在組蛋白周圍形成。核小體是一個組蛋白八聚體，由 147 個堿基對的 DNA 和 8 個核心組蛋白組成，包含 H2A、H2B、H3 和 H4 分子各兩個，組成一個 H3-H4 異四聚體和兩個 H2A-H2B 異二聚體。核小體像珠串一樣串連在一起，并被包裝成更高階的染色質結構。核心組蛋白的n端末端經歷不同的翻譯后修飾，包括乙?；?、磷酸化和甲基化，這些修飾是對細胞信號刺激的反應，對基因表達有直接影響。在大多數物種中，組蛋白 H2B 主要在賴氨酸 5、12、15 和 20 位點發(fā)生乙酰化。組蛋白 H3 主要在賴氨酸 9、14、18 和 23 位點發(fā)生乙?；?。賴氨酸 9 位點的乙酰化在某些生物的組蛋白沉積和染色質組裝中具有主導作用。在有絲分裂和減數分裂中，組蛋白 H3 的 Ser10 位點的磷酸化與染色體凝聚緊密相關。
核小體將 DNA 包裹并壓縮到染色質中，這限制了 DNA 對需要 DNA 作為模板的細胞機制的可及性。因此，組蛋白在轉錄調節(jié)、DNA 修復、DNA 復制和染色體穩(wěn)定中發(fā)揮著核心作用。DNA 可及性是通過組蛋白翻譯后修飾（也稱為組蛋白編碼）和核小體重構的復雜組合來調控的。H3 完全通過 DNA 復制偶聯途徑沉積到染色質中，該途徑可與減數分裂同源重組過程中的 DNA 復制或 DNA 修復合成相關。
亞細胞位置：細胞核，染色體。
Anti-Histone H3(Tri Methyl K4) bs-4715R
IHC 驗證數據圖
Anti-Histone H3(Nuclear Loading Control) bs-0349R
IHC 驗證數據圖
Anti-Histone H3(Nuclear Loading Control) bsm-33042M
IHC 驗證數據圖
Anti-Histone H3(tri methyl K79) bsm-33098M
IHC 驗證數據圖
Anti-Histone H3(di methyl K27) bsm-33107M
IHC 驗證數據圖
Anti-Histone H3(di methyl K36) bsm-33124M
IHC 驗證數據圖
Anti-Histone H3(di methyl K79) bsm-33123M
IHC 驗證數據圖
抗體產品列表
| 靶標名稱 | 貨號 |
交叉反應 |
應用 |
| HIST1H2BJ/Histone H2B.1 | bs-17409R | Hu | WB |
| Histone binding protein/SLBP | bs-19791R | Mo | IHC, IF, ICC |
| Histone H1.2 | bsm-54176R | Hu, Mo, Rt | WB, IHC, ICC, IF |
| Histone H1.4 (Acetyl K53) | bs-0931R | Hu, Mo | IHC, FC, IF, ICC |
| Histone H1.4 (tri methyl K25, phospho S26) | bs-17419R | Hu | IHC, IF, ICC |
| Histone H1.X | bs-17424R | Hu, Mo | WB, IHC, IF, ICC |
| Histone H1oo | bs-10335R | Mo | IHC, IF, ICC |
| Histone H1t | bs-1413R | Mo, Rt | WB |
| Histone H2A.x | bs-2560R | Hu, Mo | IHC, FC, IF, ICC |
| Histone H2A.X (Ubiquityl Lys119) | bs-8571R | Hu, Rt | IHC, FC, IF, ICC |
| Histone H2A/H2A.1 | bs-3779R | Hu, Mo, Rt | IHC, FC, IF, ICC |
| Histone H2B | bsm-33174M | Mo, Rt | IHC, IF, ICC |
| Histone H2B | bsm-52099R | Hu, Mo | IHC, FC, IF, ICC |
| Histone H2B (Acetyl K20) | bs-3783R | Rt | IHC, IF, ICC |
| Histone H3 (acetyl K14) | bsm-54178R | Hu, Mo, Rt | WB, IHC, ICC |
| Histone H3 (Acetyl K18) | bs-3775R | Hu | FC |
| Histone H3 (Acetyl K23) | bs-3774R | Hu, Mo, Rt | IHC, FC, IF, ICC |
| Histone H3 (acetyl K27) | bs-7451R | Hu, Rt | IHC, FC, IF, ICC |
| Histone H3 (acetyl K4) | bs-24644R | Hu | WB |
| Histone H3 (acetyl K9) | bs-3776R | Hu, Mo, Rt | WB, IHC, FC, IF, ICC |
| Histone H3 (acetyl K9) | bsm-33303M | Hu | IHC, IF, ICC |
| Histone H3 (Di Methyl K36) | bs-3769R | Hu, Mo, Rt | WB, IHC, FC, IF, ICC |
| Histone H3 (Di Methyl K4) | bs-3770R | Hu, Mo, Rt | WB, IHC, FC, IF, ICC |
| Histone H3 (di methyl K79) | bsm-33093M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3 (Di Methyl K9) | bs-3772R | Hu, Rt | IHC, FC, IF, ICC |
| Histone H3 (mono methyl K79) | bsm-33099M | Hu, Mo, Rt | IHC, IF, ICC |
| Histone H3 (mono methyl K79) | bsm-33109M | Hu | IHC, IF, ICC |
| Histone H3 (mono methyl K9) | bsm-33116M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3 (Nuclear Loading Control) | bs-0349R | Hu, Mo, Rt | WB, IHC, FC, IF, ICC |
| Histone H3 (Tri Methyl K27) | bs-3773R | Hu, Mo | FC |
| Histone H3 (tri methyl K36) | bs-3768R | Hu, Mo, Rt | WB, IHC, FC, IF, ICC |
| Histone H3 (tri methyl K36) | bsm-33094M | Hu, Rt | IHC, IF, ICC |
| Histone H3 (Tri Methyl K4) | bs-4715R | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3 (tri methyl K4) | bsm-33110M | Hu, Rt | IHC, IF, ICC |
| Histone H3 (tri methyl K79) | bsm-33097M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3 (tri methyl K79) | bsm-33098M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3 (tri methyl K9) | bsm-33106M | Hu, Mo, Rt | IHC, IF, ICC |
| Histone H3(di methyl K27) | bsm-33107M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3(di methyl K36) | bsm-33124M | Hu, Mo, Rt | IHC, IF, ICC |
| Histone H3(di methyl K79) | bsm-33123M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3(mono methyl K79) | bsm-33104M | Hu, Mo, Rt | IHC, IF, ICC |
| Histone H3.1 | bs-17422R | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H3.3 | bsm-52110R | Hu | IHC, IF, ICC |
| Histone H3/HIST3H3 (Nuclear Loading Control) | bsm-33042M | Hu, Mo, Rt | WB, IHC, IF, ICC |
| Histone H4 | bs-23810R | Hu, Mo | WB, IHC, IF, ICC |
| Histone H4 (Acetyl K12) | bs-3746R | Hu, Mo | WB, IHC, IF, ICC |
| Histone H4 (Acetyl K16) | bs-4707R | Mo, Rt | IHC, IF, ICC |
| Histone H4 (Acetyl K5) | bs-10721R | Hu, Rt | WB, IHC, IF, ICC |
| Histone H4 (Acetyl K8) | bs-4016R | Hu, Rt | WB, IHC, IF, ICC |
| phospho-Histone H1.4 (Thr18) | bs-3171R | Mo, Rt | IHC, IF, ICC |
| phospho-Histone H1oo (Ser20) | bs-13542R | Hu | IHC, IF, ICC |
| Phospho-Histone H2A.X (Ser139) | bs-3185R | Hu | IHC, FC, IF, ICC |
| Phospho-Histone H2A.X (Ser139) | bsm-52163R | Hu, Mo, Rt | WB, IHC, IF, ICC, |
| Phospho-Histone H2A.X (Tyr143) | bs-5360R | Hu, Mo, Rt | IHC, FC, IF, ICC |
| Phospho-Histone H3 (Ser10) | bs-3186R | Hu, Rt | IHC, FC, IF, ICC |
| Phospho-Histone H3 (Ser28) | bs-3187R | Hu | FC |
| Phospho-Histone H3 (Thr11) | bs-3188R | Hu, Rt | IHC, FC, IF, ICC |
| Phospho-Histone H3 (Thr3) | bs-3189R | Hu, Rt | IHC, FC, IF, ICC |
