| 產(chǎn)品介紹 |
Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity.
性激素結(jié)合球蛋白(SHBG),又稱睪酮—雌二醇結(jié)合球蛋白。
SHBG是一運輸性激素的載體，它在性激素人作用過程中以及在各種生理病理情況下都有一定的變化和意義。
SHBG是由母體肝臟產(chǎn)生的循環(huán)類固醇類結(jié)合球蛋白，執(zhí)行載體蛋白的功能，胰島素是肝臟合成SHBG的強大的抑制因子，胰島素抑制效應(yīng)的主要作用點在于競爭性刺激肝臟SHBG的產(chǎn)生，因而SHBG減少是高胰島素血癥、胰島素抵抗的標志。
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