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Rabbit Anti-Collagen III  antibody (bs-0549R)  
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產品編號 bs-0549R
英文名稱 Rabbit Anti-Collagen III  antibody
中文名稱 Ⅲ型膠原蛋白/膠原蛋白3/3型膠原蛋白/III型膠原抗體
別    名 COL 3A1; COL3A1; Collagen alpha 1(III) chain; Collagen III alpha 1 chain precursor; Collagen III alpha 1 polypeptide; Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant); Collagen type III alpha 1; Collagen type III alpha; EDS4A; Ehlers Danlos syndrome type IV, autosomal dominant; Fetal collagen; Type III collagen; CO3A1_HUMAN; Collagen alpha-1(III) chain; Type III collagen; type III preprocollagen alpha 1 chain.  
Specific References  (39)     |     bs-0549R has been referenced in 39 publications.
[IF=14.26] Mi Bai. et al. LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. EMBO MOL MED. 2023 Jan 11  WB ;  Mouse.  
[IF=8.718] Chao Sun. et al. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling. Exp Mol Med. 2021 Jun;53(6):1068-1079  WB ;  Human.  
[IF=8.025] Xinxin Lan. et al. Xanthan gum/oil body-microgel emulsions with enhanced transdermal absorption for accelerating wound healing. INT J BIOL MACROMOL. 2022 Sep;:  IF, WB ;  Mouse.  
[IF=7.963] Meiqiong Wu. et al. Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway. SCI TOTAL ENVIRON. 2022 Apr;:155558  WB ;  Mouse,Rat.  
[IF=7.033] Shaoyan Li. et al. Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model. INT J NANOMED. 2023 Jan 05  WB ;  Rat.  
[IF=6.633] Jia He. et al. CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin. BBA-MOL BASIS DIS. 2023 Apr;1869:166663  WB ;  Mouse,Rat.  
[IF=6.388] Yu-jie Lu. et al. Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction. PHYTOTHER RES. 2022 Oct;:  WB ;  Mouse,Human.  
[IF=5.546] Xiaoying Li. et al. Identification of YAP1 as a novel downstream effector of the FGF2/STAT3 pathway in the pathogenesis of renal tubulointerstitial fibrosis. 2021 May 16  WB ;  Mouse.  
[IF=5.5] Zhang et al. Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-β1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure. (2016) Cell.Physiol.Biochem. 39:294-303  WB ;  Rabbit.  
[IF=5.486] Manabu Takahashi. et al. Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice. J BIOL CHEM. 2022 Aug;:102322  WB ;  Mouse.  
[IF=5.34] Bo Liang. et al. Guanxin V protects against ventricular remodeling after acute myocardial infarction through the interaction of TGF-β1 and Vimentin. Phytomedicine. 2022 Jan;95:153866  IHC ;  Hamsters.  
[IF=5.169] Pasinlio?lu Burak. et al. Comparison of the Effects of Skin Microneedling with Cupping Therapy and Microneedling Alone: An Experimental Study’’. PLAST RECONSTR SURG. 2023 Jan;:10.1097/PRS.0000000000010134  IHC ;  Rat.  
[IF=5.168] Yu, Chengyuan, et al. "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." Oncotarget 8.23 (2017): 37705.  WB ;  Dog.  
[IF=4.967] Helei Li. et al. Matrix Regeneration Ability In Situ Induced by a Silk Fibroin Small-Caliber Artificial Blood Vessel In Vivo. POLYMERS-BASEL. 2022 Jan;14(18):3754  IHC ;  Rabbit.  
[IF=4.545] Kai Zhao. et al. Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model. Biomed Pharmacother. 2021 Jun;138:111466  IF ;  Rat.  
[IF=4.164] Chengnan Tian. et al. CREB1 transcription-activated lncRNA PVT1 promotes cardiac fibrosis via miR-145/HCN1 axis. Int J Cardiol. 2022 Jan;:  WB ;  Mouse,Human.  
[IF=4.119] Siyu Li. et al. Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis. 2021 Sep 27  WB ;  mouse.  
[IF=3.94] Peiran Cong. et al. Hydroxysafflor yellow A mitigates myocardial fibrosis induced by isoproterenol and angiotensin II. AM J TRANSL RES. 2022; 14(12): 8588–8598  WB ;  Mouse.  
[IF=3.913] Xiaoliang Zhou. et al. Ursolic acid inhibits human dermal fibroblasts hyperproliferation, migration, and collagen deposition induced by TGF-β via regulating the Smad2/3 pathway. GENE. 2023 May;867:147367  WB ;  Human.  
[IF=3.869] Chen Guanyin. et al. Hypoxia-Induced Mesenchymal Stem Cells Exhibit Stronger Tenogenic Differentiation Capacities and Promote Patellar Tendon Repair in Rabbits. Stem Cells Int. 2020;2020:8822609  WB ;  Rabbit.  
[IF=3.738] Lijun Zhang. et al. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. INT J MED SCI. 2022; 19(5): 952–964  IHC ;  Human.  
[IF=3.715] Nan Hou. et al. Tissue-engineered esophagus: recellular esophageal extracellular matrix based on perfusion-decellularized technique and mesenchymal stem cells. Biomed Mater. 2021 Aug;:  IHC ;  Rabbit.  
[IF=3.423] Qi-Lin Lu. et al. Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. MOL MED REP. 2022 Sep;26(3):1-9  WB ;  Human.  
[IF=3.375] Wei P. et al. Nintedanib ameliorates tracheal stenosis by activating HDAC2 and suppressing IL-8 and VEGF in rabbit.. Am J Transl Res. 2020 Aug;12(8):4739-4748  IHC ;  Rabbit.  
[IF=3.297] Hao Chen. et al. MicroRNA-124-3p affects myogenic differentiation of adipose-derived stem cells by targeting Caveolin-1 during pelvic floor dysfunction in Sprague Dawley rats. Ann Transl Med. 2021 Jan; 9(2): 161  WB ;  Rat.  
[IF=3.201] Shang L et al. Elevated β1-Adrenergic Receptor Autoantibody Levels Increase Atrial Fibrillation Susceptibility by Promoting Atrial Fibrosis. Frontiers in Physiology,(2020) 11.  WB ;  Rabbit.  
[IF=2.976] Elena Martínez-Sanz. et al. Study of the functional relationships between the buccinator muscle and the connective tissue of the cheek in humans. ANN ANAT. 2022 Nov;:152025  IHC ;  Human.  
[IF=2.894] Shen, Zhou. et al. Bone marrow mesenchymal stem cells therapy on bilateral pelvic nerve crush-induced voiding dysfunction in rats. INT UROGYNECOL J. 2022 Apr;:1-8  WB ;  Rat.  
[IF=2.833] Xiaoxiao Zhang. et al. Effect of Guanxin V in animal model of acute myocardial infarction. Bmc Complem Altern M. 2021 Dec;21(1):1-11  IHC ;  Hamster.  
[IF=2.74] Xiaoyan Sun. et al. Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts. Plos One. 2021 Apr;16(4):e0249977  WB ;  Human.  
研究領域 細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Rabbit,Dog (predicted: Mouse,Rat,Cow,Chicken)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 117kDa
細胞定位 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Collagen alpha 1(III) chain: 1301-1400/1466 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Function:
Collagen type III occurs in most soft connective tissues along with type I collagen.

Subunit:
Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Post-translational modifications:
Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

DISEASE:
Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.
Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.

Similarity:
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain.

SWISS:
P02461

Gene ID:
1281

Database links:

Entrez Gene: 1281 Human

Entrez Gene: 12825 Mouse

Entrez Gene: 84032 Rat

Omim: 120180 Human

SwissProt: P02461 Human

SwissProt: P08121 Mouse

SwissProt: P13941 Rat

Unigene: 443625 Human

Unigene: 249555 Mouse

Unigene: 3247 Rat



產品圖片
Sample: Lane 1: Human HeLa cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-Collagen III (bs-0549R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 117 kDa Observed band size: 130 kDa
Tissue/cell: human myocardium tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Collagen III Polyclonal Antibody, Unconjugated(bs-0549R) 1:400, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: dog bladder tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Collagen III Polyclonal Antibody, Unconjugated(bs-0549R) 1:800, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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