| 產(chǎn)品編號(hào) | bs-0315R |
| 英文名稱 | Rabbit Anti-FGL2 antibody |
| 中文名稱 | 凝血酶原酶/纖維蛋白原2抗體 |
| 別 名 | Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN. |
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Specific References (1) | bs-0315R has been referenced in 1 publications.
[IF=34.661] Yang, Siyoung, et al. "Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance." Science 348.6234 (2015): 589-594. FCM ; Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 49kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Rat FGL2: 75-150/422 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1. Function: May play a role in physiologic lymphocyte functions at mucosal sites Subunit: Homotetramer; disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: Constitutively expressed in cytotoxic T-cells. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: N/A Gene ID: 84586 Database links: Entrez Gene: 10875 Human Entrez Gene: 14190 Mouse Omim: 605351 Human SwissProt: Q14314 Human SwissProt: P12804 Mouse Unigene: 520989 Human Unigene: 292100 Mouse fgL-2蛋白是新近發(fā)現(xiàn)的一種凝血因子，它通過(guò)直接激活凝血酶原啟動(dòng)凝血過(guò)程。一 系列實(shí)驗(yàn)證明，該蛋白在肝細(xì)胞壞死中起到重要作用。對(duì)乙肝患者肝組織免疫組織化學(xué)染色hfg12在重型乙型肝炎患者高表達(dá)。 凝血酶原酶(簡(jiǎn)稱fgl2)蛋白屬于纖維蛋白原家族的一員,由活化的巨噬細(xì)胞表達(dá),具有凝血酶原酶的活力,能催化凝血酶原轉(zhuǎn)化為凝血酶,啟動(dòng)凝血過(guò)程. |
| 產(chǎn)品圖片 |
Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-fg-12 Polyclonal Antibody, Unconjugated(bs-0315R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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