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Rabbit Anti-GAP43  antibody (bs-0154R)  
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產(chǎn)品編號 bs-0154R
英文名稱 Rabbit Anti-GAP43  antibody
中文名稱 神經(jīng)生長相關(guān)蛋白43抗體
別    名 Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.  
Specific References  (7)     |     bs-0154R has been referenced in 7 publications.
[IF=15.84] Han Yang. et al. A Novel Targeted and High‐Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease. Adv Sci. 2020 Oct;7(19):1902906  IF,FC ;  Mouse.  
[IF=5.546] Yifan Wang. et al. Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force. J Cell Physiol. 2021 Mar;236(3):2156-2168  IF ;  Human.  
[IF=4.73] Erdal Ayhan I?ik. et al. Use of Erythropoietin and Fibrin Glue Mixture for Peripheral Nerve Repair. Plast Reconstr Surg. 2022 Feb;149(2):395-403  IHC ;  Rat.  
[IF=4.411] Pingan Chen. et al. The influence of inhibiting renal neural regeneration on the efficacy of renal denervation to chronic heart failure. 2021 Oct 22  WB ;  Rat.  
[IF=3.297] Sheng Cao. et al. Ultrasound-targeted microbubble destruction-mediated Ang1 gene transfection improves left ventricular structural and sympathetic nerve remodeling in canines with myocardial infarction. Ann Transl Med. 2021 Feb; 9(3): 221  IHC ;  Dog.  
[IF=2.733] Zhai X et al. L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model. Brain Res. 2020 Nov 1;1746:146945.  IHF ;  Rat.  
[IF=1.931] Jiang et al. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model. (2016) Evid.Based.Complement.Alternat.Med. 2016:3617216  In Vitro/IHC ;  Rat.  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Chicken,Dog)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:200-800
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì) 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GAP43: 9-100/238 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Subunit:
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Post-translational modifications:
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

Similarity:
Belongs to the neuromodulin family.
Contains 1 IQ domain.

SWISS:
P06837

Gene ID:
2596

Database links:

Entrez Gene: 2596 Human

Entrez Gene: 14432 Mouse

Entrez Gene: 29423 Rat

GenBank: NP_002036 Human

Omim: 162060 Human

SwissProt: P17677 Human

SwissProt: P06837 Mouse

SwissProt: P07936 Rat

Unigene: 134974 Human

Unigene: 1222 Mouse

Unigene: 10928 Rat



神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology);神經(jīng)標(biāo)志物
GAP43 (Growth associated protein-43)又稱作neuromodulin,是一個(gè)軸突膜蛋白,是一種神經(jīng)特異性的蛋白質(zhì),參與神經(jīng)細(xì)胞外生長及突觸發(fā)育形成和神經(jīng)細(xì)胞再生。在神經(jīng)元發(fā)育和再生過程中以高水平表達(dá)。能調(diào)解軸突延伸作用,改變細(xì)胞形態(tài)。作為細(xì)胞內(nèi)信號,可大大增強(qiáng)與G蛋白偶聯(lián)的受體轉(zhuǎn)運(yùn)作用。
神經(jīng)生長相關(guān)蛋白-GAP-43和神經(jīng)細(xì)胞黏附因子(neural cell adhesion molecule,NCAM)與突觸可塑性密切相關(guān).GAP-43是一種神經(jīng)細(xì)胞膜上的特異性磷蛋白,在神經(jīng)發(fā)育和再生過程中呈現(xiàn)高表達(dá),被作為突觸生長的標(biāo)志物,有稱脊髓生長相關(guān)蛋白
GAP-43與CaM結(jié)合,參與G蛋白相互作用,神經(jīng)遞質(zhì)的釋放,作用于胞吞/胞吐過程,通過小囊溶合或誘導(dǎo)生長錐和突觸前末端的胞吞促進(jìn)膜擴(kuò)展,與海馬長時(shí)程增強(qiáng)密切相關(guān).
神經(jīng)細(xì)胞黏附因子是細(xì)胞表面糖蛋白大家族的成員之一,促進(jìn)軸突生長,對長時(shí)記憶的保持有重要影響,同時(shí),GAP-43對其具調(diào)節(jié)作用,廣泛而深入地研究GAP-43意義深遠(yuǎn)。
產(chǎn)品圖片
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GAP-43 Polyclonal Antibody, Unconjugated(bs-0154R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Paraformaldehyde-fixed, paraffin embedded (Human glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GAP43) Polyclonal Antibody, Unconjugated (bs-0154R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (bs-0295G-FITC) for 90 minutes, and DAPI for nuclei staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GAP43) Polyclonal Antibody, Unconjugated (bs-0154R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (bs-0295G-FITC) for 90 minutes, and DAPI for nuclei staining.
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