| 產(chǎn)品編號 | bs-1081R |
| 英文名稱 | Rabbit Anti-OPCML antibody |
| 中文名稱 | 阿片樣物質(zhì)結(jié)合蛋白/細(xì)胞粘附分子樣蛋白抗體 |
| 別 名 | opioid binding protein/cell adhesion molecule-like; OPCML; OBCAM; OPCM; 3732419F12; C230027C17; 2900075O15RIK; AI844366; B930023M13RIK; Gm181; IGLON1; MGC99974; OPCM_HUMAN; Opioid-binding protein/cell adhesion molecule. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Rabbit,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 35kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OPCML: 101-200/345 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Function: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Subcellular Location: Cell membrane. DISEASE: Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Similarity: Belongs to the immunoglobulin superfamily. IgLON family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q14982 Gene ID: 4978 Database links: Entrez Gene: 4978 Human Omim: 600632 Human SwissProt: Q14982 Human Unigene: 4817 Human Unigene: 720580 Human OPCML基因的作用是產(chǎn)生一種能幫助卵巢表面分子粘合在一起的蛋白質(zhì)，當(dāng)這一基因關(guān)閉后，細(xì)胞間的粘合力減弱，此時如細(xì)胞加速生長，即有可能產(chǎn)生早期癌變。 經(jīng)研究發(fā)現(xiàn)，OPCML能夠增加細(xì)胞的黏附能力,抑制癌細(xì)胞的增殖,OPCML可能是一個新的抑癌基因.在早期病癥中能抑制癌變細(xì)胞蛋白質(zhì)的生成，并有效阻止癌變細(xì)胞的生長。 |
| 產(chǎn)品圖片 |
Tissue/cell: rat ovary tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-OPCML Polyclonal Antibody, Unconjugated(bs-1081R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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