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Rabbit Anti-IL13  antibody (bs-0560R)  
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產品編號 bs-0560R
英文名稱 Rabbit Anti-IL13  antibody
中文名稱 白介素13抗體
別    名 Interleukin-13; Interleukin 13; Interleukin13; ALRH; BHR 1; BHR1; IL 13; IL-13; MGC116786; MGC116788; MGC116789; NC30; P600; Interleukin-13; T-cell activation protein P600; IL13_MOUSE; IL13_HUMAN.  
Specific References  (7)     |     bs-0560R has been referenced in 7 publications.
[IF=17.694] Glaubitz, Juliane. et al. In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response. NAT COMMUN. 2022 Aug;13(1):1-20  FC ;  Mouse.  
[IF=11.467] Yingzheng Zhao. et al. In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot. J CONTROL RELEASE. 2022 Oct;350:93  IHC ;  Rat.  
[IF=9.038] Bin Li. et al. lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity. J Hazard Mater. 2021 Aug;416:125878  WB ;  Mouse.  
[IF=5.249] Liang, Wei. et al. Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment. 2021 Sep 27  WB ;  Rat.  
[IF=3.115] Jing L et al. Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats. J Ethnopharmacol. 2019 May 10;235:424-434.  IHC-P&WB ;  Rat.  
[IF=1.785] Ying Xue. et al. Application of TGF?β1, TIMP?1 and TIMP?2 small interfering RNAs can alleviate CCl4?induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines. Exp Ther Med. 2021 Sep;22(3):1-7  WB,IHC ;  Rat.  
[IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.  WB ;  Mouse.  
研究領域 腫瘤  細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 12kDa
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-13: 45-56/131(mo) 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]


Function:
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subcellular Location:
Secreted.

DISEASE:
Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Similarity:
Belongs to the IL-4/IL-13 family.

SWISS:
P20109

Gene ID:
16163

Database links:

Entrez Gene: 3596 Human

Entrez Gene: 16163 Mouse

Entrez Gene: 116553 Rat

Omim: 147683 Human

SwissProt: P35225 Human

SwissProt: P20109 Mouse

SwissProt: P42203 Rat

Unigene: 845 Human

Unigene: 1284 Mouse

Unigene: 9921 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (bs-0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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