| 產(chǎn)品編號(hào) | bs-0280R |
| 英文名稱 | Rabbit Anti-PLGF antibody |
| 中文名稱 | 胎盤(pán)生長(zhǎng)因子抗體 |
| 別 名 | Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein. |
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Specific References (4) | bs-0280R has been referenced in 4 publications.
[IF=13.352] Guangdong Bai. et al. Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function. ENVIRON INT. 2022 Dec;170:107579 WB ; Pig.
[IF=3.24] Enoch Odame Anto. et al. Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia. Plos One. 2022 Mar;17(3):e0265717 IHC ; Human.
[IF=2.7] Zhang, Liang, et al. "Placenta growth factor contributes to cell apoptosis and epithelial-to-mesenchymal transition in the hyperoxia-induced acute lung injury." Life Sciences (2016). WB ; Rat.
[IF=2.47] Zhang, Liang, et al. "Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway." International Immunopharmacology 38 (2016): 167-174. WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Mouse,Pig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse PLGF: 101-158/158 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Subunit: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Subcellular Location: Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. Tissue Specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. Post-translational modifications: N-glycosylated. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P49764 Gene ID: 18654 Database links: Entrez Gene: 5228 Human Entrez Gene: 18654 Mouse Omim: 601121 Human SwissProt: P49763 Human SwissProt: P49764 Mouse Unigene: 252820 Human Unigene: 4809 Mouse Unigene: 6960 Rat PLGF胎盤(pán)生長(zhǎng)因子是血管生長(zhǎng)因子家族成員之一（又稱：胎盤(pán)型血管內(nèi)皮細(xì)胞生長(zhǎng)因子），是動(dòng)脈粥樣硬化斑塊不穩(wěn)定的主要炎性激活物，因此它可作為ACS患者風(fēng)險(xiǎn)預(yù)測(cè)的生物學(xué)標(biāo)志物.尿胎盤(pán)生長(zhǎng)因子水平可預(yù)測(cè)先兆子癇危險(xiǎn).研究人員發(fā)現(xiàn)，在疾病發(fā)作前的6到8周，先兆子癇患者尿液中的胎盤(pán)生長(zhǎng)因子水平急劇下降,這種新的尿檢方法使提前1到2個(gè)月預(yù)測(cè)先兆子癇成為可能。亦有研究人員正在從事胎盤(pán)生長(zhǎng)因子與肺氣腫，胃癌，腸癌等方面的研究。 |
| 產(chǎn)品圖片 |
Sample: Placenta (Rat) Lysate at 30 ug
Primary: rabbit Anti-PLGF (bs-0280R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution;
Predicted band size:16 kD
Observed band size:16 kD
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