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Rabbit Anti-SOD2  antibody (bs-1080R)  
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產(chǎn)品編號 bs-1080R
英文名稱 Rabbit Anti-SOD2  antibody
中文名稱 超氧化物歧化酶2抗體
別    名 IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.  
Specific References  (19)     |     bs-1080R has been referenced in 19 publications.
[IF=6.208] Qiyang Yao. et al. Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome. INT J MOL SCI. 2022 Jan;23(19):11384  WB ;  Mouse.  
[IF=6.1] Yun, Yang, et al. "Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically Regulating the Epithelial-to-Mesenchymal Transition (EMT)." Environmental Science & Technology (2017).  WB ;  Human.  
[IF=6.081] Naoki Yoshida. et al. Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer’s Disease Transgenic Mouse Brains. Biomedicines. 2022 Feb;10(2):281  WB ;  Mouse.  
[IF=6.064] Mengni Bao. et al. N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway. BIOMOLECULES. 2022 Sep;12(9):1195  WB ;  Mouse, Rat.  
[IF=6.025] Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078  WB ;  Mouse.  
[IF=5.279] Lei Wang. et al. Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder. J Agr Food Chem. 2022;70(4):1163–1173  WB ;  Mouse.  
[IF=5.23] Zhao, Yong, et al. "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." Scientific Reports 6 (2016): 37884.  WB ;  Pig.  
[IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.  
[IF=4.2] Yuan, Qing, et al. "Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." International Journal of Nanomedicine 9 (2014): 4829.  WB ;  Mouse.  
[IF=3.85] Wang, Yandi, et al. "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." Toxicology and Applied Pharmacology (2016).  IHC-P ;  Sheep.  
[IF=3.647] Lin D et al. Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion. Life Sci . 2020 Jul 15;253:117705.  IHC,WB ;  mouse.  
[IF=3.47] Minjeong Kim. et al. Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress. Biomol Ther. 2021 Mar 1; 29(2): 205–210  WB ;  Human.  
[IF=3.038] Lan Yang et al. The Involvement of Mitochondrial Biogenesis in Selenium Reduced Hyperglycemia-Aggravated Cerebral Ischemia Injury. Neurochem Res. 2020 Aug;45(8):1888-1901.  WB ;  Mouse.  
[IF=2.884] Faria AVS et al. LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells. Mol Cell Biochem. 2020 Mar;466(1-2):83-89.  WB ;  Human.  
[IF=2.721] Yang, Ke. et al. Comparisons between needle puncture and chondroitinase ABC to induce intervertebral disc degeneration in rabbits. EUR SPINE J. 2022 Jun;:1-13  WB ;  Rabbit.  
[IF=2.21] Khan, Md Asaduzzaman, et al. "Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells." Molecules and cells (2013): 1-7.  WB ;  Human.  
[IF=1.832] Gao J et al. Proteomic Analyses of Mammary Glands Provide Insight into the Immunity and Metabolism Pathways Associated with Clinical Mastitis in Meat Sheep.Animals (Basel). 2019 May 31;9(6). pii: E309.  WB ;  Sheep.  
[IF=0] Hermawati E et al. Spatial Memory Disturbance Following Transient Brain Ischemia is Associated with Vascular Remodeling in Hippocampus. Kobe J Med Sci.?2018 Oct 15;64(3):E93-E106.  IHC-P ;  Rat.  
[IF=0] SUKADANA IM et al. The Intake of Inocarpus Fagiferus Fosb Stem Bark N-Buthanol Extract Caused the Increase Expression of Sod-2 and Sod-3 Aortic Endhotelial Cells of Hypercholesterolemia Rats. Biomedical and Pharmacology Journal.2017,?10(4):1773-1777?·  WB ;  Rat.  
研究領(lǐng)域 神經(jīng)生物學  細胞凋亡  激酶和磷酸酶  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22kDa
細胞定位 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOD2: 41-78/222 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Subunit:
Homotetramer.

Subcellular Location:
Mitochondrion matrix.

Post-translational modifications:
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.

DISEASE:
Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the iron/manganese superoxide dismutase family.

SWISS:
P04179

Gene ID:
6648

Database links:

Entrez Gene: 374042 Chicken

Entrez Gene: 281496 Cow

Entrez Gene: 476258 Dog

Entrez Gene: 6648 Human

Entrez Gene: 20656 Mouse

Entrez Gene: 100154319 Pig

Entrez Gene: 24787 Rat

Omim: 147460 Human

SwissProt: P41976 Cow

SwissProt: P04179 Human

SwissProt: P09671 Mouse

SwissProt: P41982 Rabbit

SwissProt: P07895 Rat

Unigene: 487046 Human

Unigene: 290876 Mouse

Unigene: 10488 Rat



SOD2是清除線粒體氧自由基的最主要的酶類,SOD2參與促進細胞分化和腫瘤發(fā)生。SOD2的表達缺乏與血管病變、新生兒致死、神經(jīng)退行性病變有關(guān)聯(lián)。SOD2過度表達與抵御細胞氧化損傷有關(guān)。
超氧化物歧化酶又稱(Superoxide dismutase,簡稱SOD)是參與機體抗氧化(ROS,反應性氧離子reactive oxygen species)防御機制和抵御細胞氧化損傷最重要的酶類之一, 廣泛存在于需氧生物、耐氧生物及某些厭氧微生物中,目前已知的SOD 主要分為三類,即胞質(zhì)中Cu/Zn-SOD(即SOD1)、線粒體中的Mn-SOD(即SOD2)和ec-SOD(即SOD3)。
產(chǎn)品圖片
Sample: Heart(Mouse) lysate at 30ug; Primary: Anti-SOD2 (bs-1080R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G-HRP) at 1: 5000 dilution; Predicted band size :22kD Observed band size : 19kD
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