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Rabbit Anti-TRF1  antibody (bs-1151R)  
~~~促銷(xiāo)代碼KT202411~~~
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產(chǎn)品編號(hào) bs-1151R
英文名稱(chēng) Rabbit Anti-TRF1  antibody
中文名稱(chēng) 端粒體復(fù)制結(jié)合因子1抗體
別    名 hTRF1 AS; NIMA interacting protein 2; NIMA-interacting protein 2; PIN 2; PIN2; t TRF1; Telomeric protein Pin2; Telomeric protein Pin2/TRF1; Telomeric repeat binding factor (NIMA interacting) 1; Telomeric repeat binding factor 1; Telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF 1; TERF1; TERF1_HUMAN; TRBF 1; TRBF1; TRF 1; TRF; TTAGGG repeat binding factor 1; TTAGGG repeat-binding factor 1.  
Specific References  (7)     |     bs-1151R has been referenced in 7 publications.
[IF=8.755] Chunfeng Lu. et al. ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized?PINK1/Parkin-mediated mitophagy. CELL PROLIFERAT. 2022 Dec;:e13378  WB ;  Human.  
[IF=6.831] Xiaoyu Qi. et al. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. 2021 Aug 03  WB ;  Hamsters.  
[IF=6.691] Jiang, Yiming. et al. Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. 2021 Aug 17  IF ;  Mouse.  
[IF=5.988] Qi Xiaoyu. et al. Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease. FRONT PHARMACOL. 2022 Jun;0:2140  WB ;  Human, Mouse.  
[IF=3.376] Esra Gozde Kosebent et al. The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse. Exp Gerontol. 2020 Sep;138:110975.  IHC ;  Mouse.  
[IF=2.829] Fatma Uysal. et al. Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. J Assist Reprod Gen. 2021 Feb;38(2):429-441  IHC ;  Human.  
[IF=1.951] Esra G. Kosebent. et al. The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes. 2021 Feb 05  IHC ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRBF1: 121-220/439 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq].

Function:
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Subunit:
Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation. Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interactions with GNL3L and TIN2 are mutually exclusive (By similarity).

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.

Tissue Specificity:
Highly expressed and ubiquitous. Isoform Pin2 predominates.

Post-translational modifications:
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.

Similarity:
Contains 1 HTH myb-type DNA-binding domain.

SWISS:
P54274

Gene ID:
7013

Database links:

Entrez Gene: 7013 Human

Entrez Gene: 21749 Mouse

Omim: 600951 Human

SwissProt: P54274 Human

SwissProt: P70371 Mouse

Unigene: 442707 Human

Unigene: 4306 Mouse



TRBF1端粒體復(fù)制結(jié)合因子1,在細(xì)胞周期的過(guò)程中都有該蛋白的存在,可抑制端粒酶的活性,限制染色體頂端的延長(zhǎng)。端粒體復(fù)制結(jié)合因子1位于端粒體頂端,是端粒體核酸蛋白復(fù)合物的組成部分。
產(chǎn)品圖片
Sample: K562(Human) Cell Lysate at 30 ug Primary: Anti-TRF1 (bs-1151R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 49 kD
Sample: HL-60(Human) Cell Lysate at 30 ug Primary: Anti-TRF1 (bs-1151R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 49 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRF1) Polyclonal Antibody, Unconjugated (bs-1151R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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