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Rabbit Anti-Integrin alpha E  antibody (bs-1274R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-1274R
英文名稱 Rabbit Anti-Integrin alpha E  antibody
中文名稱 整合素αE(CD103)抗體
別    名 alpha-E1; alpha-M290; aM290; Antigen CD103; CD 103; CD103; CD103 antigen; HML 1 antigen; HML1 antigen; Human mucosal lymphocyte antigen 1; Human mucosal lymphocyte antigen 1, alpha subunit; Huminae; Integrin alpha E heavy chain; Integrin alpha E light chain; Integrin alpha E, epithelial-associated; Integrin alpha E1; Integrin alpha IEL; Integrin alpha M290; Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); Integrin, alpha E; ITGAE; MGC141996; MGC183601; Mucosal lymphocyte 1 antigen; Mucosal lymphocyte antigen 1;   Integrin αE.
Specific References  (1)     |     bs-1274R has been referenced in 1 publications.
[IF=1.851] Li Y et al. Role of CCR7 on dendritic cell?mediated immune tolerance in the airways of allergy?induced asthmatic rats. Mol Med Rep. 2019 Sep 20.  WB ;  Rat.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞粘附分子  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
檢測分子量 25/150
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha-E heavy chain: 1001-1179/1179 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

Function:
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

SWISS:
P38570

Gene ID:
3682

Database links:

Entrez Gene: 3682 Human

Omim: 604682 Human

SwissProt: P38570 Human

Unigene: 513867 Human



產(chǎn)品圖片
Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-Integrin alpha E (bs-1274R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 128 kD Observed band size: 128 kD
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