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Rabbit Anti-TNF beta  antibody (bs-0093R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-0093R
英文名稱 Rabbit Anti-TNF beta  antibody
中文名稱 腫瘤壞死因子β抗體
別    名 TNF-beta; LTalpha; Coley’s toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT alpha; LT; LTA; Lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Natural killer cytotoxic factor; Necrosin; NKCF; OTTHUMP00000037612; OTTHUMP00000037613; TNF B; TNF superfamily member 1; TNFbeta; TNFSF 1; TNFSF1; Tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNFB_HUMAN;   TNF β; TNF-β.
Specific References  (2)     |     bs-0093R has been referenced in 2 publications.
[IF=2.738] Liang Wang et al. Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis. Dis Markers. 2020 May 20;2020:2509454.  IHC ;  Human.  
[IF=1.826] Fei W et al. The effects of aqueous extract of Maca on energy metabolism and immunoregulation. Eur J Med Res. 2020 Jun 29;25(1):24.  WB ;  Mouse.  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 18kDa
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNF beta: 91-205/205 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha.

Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Subunit:
Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.

Subcellular Location:
Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.

DISEASE:
Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae.
Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.

Similarity:
Belongs to the tumor necrosis factor family.

SWISS:
P01374

Gene ID:
4049

Database links:

Entrez Gene: 4049 Human

Entrez Gene: 16992 Mouse

Entrez Gene: 25008 Rat

Omim: 153440 Human

SwissProt: P01374 Human

SwissProt: P09225 Mouse

SwissProt: Q06332 Rat

Unigene: 36 Human

Unigene: 87787 Mouse

Unigene: 160577 Rat



生長因子和激素
腫瘤壞死因子-β(TNF β)是多功能細胞因子,又稱淋巴毒素(Lymphotoxin,LT)是由活化淋巴細胞所產生,它具有抗腫瘤、抗病毒、誘導成纖維細胞、B細胞和胸腺細胞的增殖、分化以及調節(jié)免疫功能等廣泛的生物學效應。
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