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Rabbit Anti-Syndecan-1  antibody (bs-1309R)  
~~~促銷(xiāo)代碼KT202411~~~
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產(chǎn)品編號(hào) bs-1309R
英文名稱(chēng) Rabbit Anti-Syndecan-1  antibody
中文名稱(chēng) 多配體蛋白聚糖1(CD138)抗體
別    名 SDC1; SDC; SYND1; Syndecan I; SyndecanI; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.  
Specific References  (9)     |     bs-1309R has been referenced in 9 publications.
[IF=5.763] You Shuang. et al. Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation. REGEN BIOMATER. 2023 Apr;:  IHC ;  Rat.  
[IF=5.733] Jiang Yufei. et al. Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation. Hum Reprod. 2020 Nov;35(11):2439-2453  IP ;  Human.  
[IF=4.831] Linlin Yanget al. CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis. Aging (Albany NY) . 2020 Jul 13;12(13):13668-13683.  IHC, IF ;  Human.  
[IF=3.616] Shugen Xu. et al. Effect of miR-21-3p on lung injury in rats with traumatic hemorrhagic shock resuscitated with sodium bicarbonate Ringer’s solution. ANN TRANSL MED. 2022 Dec; 10(24): 1331  WB ;  Rat.  
[IF=2.97] Hambruch, N., et al. "Bovine placentomal heparanase and syndecan expression is related to placental maturation." Placenta.  IHC-P ;  Bovine.  
[IF=2.65] Miyatani, Kozo, et al. "A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis." Virchows Archiv (2016): 1-9.  IHC-F ;  Human.  
[IF=2.54] Chen, Song, et al. "Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis." Journal of Histochemistry & Cytochemistry (2017): 0022155417692536.  IHC-P ;  Mouse.  
[IF=2.273] Haibo Xie. et al. Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury:. TOXICOL IND HEALTH. 2022;38(5):287-298  WB ;  Mouse.  
[IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  細(xì)胞膜受體  細(xì)胞粘附分子  細(xì)胞表面分子  糖蛋白  上皮細(xì)胞  內(nèi)皮細(xì)胞  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat,Cow (predicted: Rabbit,Pig,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34kDa
檢測(cè)分子量 60-70
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD138: 201-310/310 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Subunit:
Interacts with CDCP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Similarity:
Belongs to the syndecan proteoglycan family.

SWISS:
P18827

Gene ID:
6382

Database links:

Entrez Gene: 6382 Human

Entrez Gene: 20969 Mouse

Entrez Gene: 25216 Rat

Omim: 186355 Human

SwissProt: P18827 Human

SwissProt: P18828 Mouse

SwissProt: P26260 Rat

Unigene: 224607 Human

Unigene: 665958 Human

Unigene: 2580 Mouse

Unigene: 11176 Rat



Syndecan1(CD138)屬于Syndecans基因家族,該家族是一類(lèi)細(xì)胞表面跨膜蛋白多糖 ,是膜表面粘附受體 ,參與細(xì)胞-細(xì)胞外基質(zhì)之間的粘附。
CD138表達(dá)于上皮細(xì)胞、胚胎間質(zhì)細(xì)胞、血管平滑肌細(xì)胞、內(nèi)皮細(xì)胞和神經(jīng)細(xì)胞基底膜。Syndecan-1與惡性腫瘤的發(fā)生發(fā)展、浸潤(rùn)及轉(zhuǎn)移有關(guān),著色于胞漿和胞膜.
產(chǎn)品圖片
Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Mouse Liver tissue lysates Lane 3: Human U251 cell lysates Lane 4: Human A431 cell lysates Lane 5: Human HepG2 cell lysates Lane 6: Human HeLa cell lysates Primary: Anti-Syndecan-1 (bs-1309R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kDa Observed band size: 74 kDa
Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Syndecan-1) Polyclonal Antibody, Unconjugated (bs-1309R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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