| 產(chǎn)品編號(hào) | bs-1518R |
| 英文名稱 | Rabbit Anti-Persephin antibody |
| 中文名稱 | PSP抗體 |
| 別 名 | PSPN_HUMAN; PSP. |
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Specific References (1) | bs-1518R has been referenced in 1 publications.
[IF=5.076] Asally R et al.The Expression and Cellular Localisation of Neurotrophin and Neural Guidance Molecules in Peritoneal Ectopic Lesions.Mol Neurobiol. 2018 Sep 25 IHC ; Rat.
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| 研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 14kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Persephin: 51-156/156 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016] Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Subunit: Homodimer; disulfide-linked. Subcellular Location: Secreted. Similarity: Belongs to the TGF-beta family. GDNF subfamily. SWISS: O60542 Gene ID: 5623 Database links: Entrez Gene: 5623 Human Omim: 602921 Human SwissProt: O60542 Human Unigene: 248159 Human 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） PSP是TGF-β家族的一個(gè)新亞族，該亞族還有其他三個(gè)成員：Neurturin(NTN)、GDNF和Artemin(ART)，它們均不同程度地對(duì)多巴胺神經(jīng)元、脊髓前角運(yùn)動(dòng)神經(jīng)元、背根神經(jīng)節(jié)、頸上神經(jīng)節(jié)以及腎等非神經(jīng)元細(xì)胞都具有生長促進(jìn)作用。研究表明膠質(zhì)細(xì)胞系源性神經(jīng)營養(yǎng)因子,主要用于PD的研究。 |
