| 產(chǎn)品編號 | bs-1782R |
| 英文名稱 | Rabbit Anti-TFRC antibody |
| 中文名稱 | 轉(zhuǎn)鐵蛋白受體（CD71）抗體 |
| 別 名 | Transferrin receptor protein 1; Transferrin receptor; CD71; CD 71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TR; sTfR; Transferrin receptor (p90 CD71); TRFR; TFR1_HUMAN. |
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Specific References (6) | bs-1782R has been referenced in 6 publications.
[IF=3.367] Hua Chen. et al. Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats. Front Physiol. 2021; 12: 639454 IHC ; Rat.
[IF=2.88] Gao, Yuhua, et al. "Isolation and Characterization of Chicken Dermis-Derived Mesenchymal Stem/Progenitor Cells." BioMed Research International 2013 (2013). Chicken.
[IF=2.634] Ma?C et al. Identification and Multilineage Potential Research of a Novel Type of Adipose-Derived Mesenchymal Stem Cells from Goose Inguinal Groove. DNA Cell Biol. 2018 Sep;37(9):731-741. ICF ; Goose.
[IF=1.69] Gao, Yuhua, et al. "All-trans Retinoic Acid Promotes Nerve Cell Differentiation of Yolk Sac-Derived Mesenchymal Stem Cells." Applied Biochemistry and Biotechnology (2014): 1-11. Chicken.
[IF=1.41] Lu T et al. In vitro culture and biological properties of broiler adipose?derived stem cells.Exp Ther Med. 2018 Sep;16(3):2399-2407. ICF&FITC ; broiler.
[IF=0] Lan B et al. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine. 2020. IHC-P ; Rat.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 干細(xì)胞 糖尿病 細(xì)胞表面分子 細(xì)胞類型標(biāo)志物 淋巴細(xì)胞 t-淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD71: 21-120/760 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferring for an overlapping C-terminal binding site. Subunit: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted Post-translational modifications: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. Similarity: Belongs to the peptidase M28 family. M28B subfamily. Contains 1 PA (protease associated) domain. SWISS: P02786 Gene ID: 7037 Database links: Entrez Gene: 7037 Human Entrez Gene: 22042 Mouse Omim: 190010 Human SwissProt: P02786 Human SwissProt: Q62351 Mouse Unigene: 529618 Human Unigene: 28683 Mouse Unigene: 98672 Rat 轉(zhuǎn)鐵蛋白及轉(zhuǎn)鐵蛋白受體(TfnrR)是機(jī)體鐵代謝中的重要因子，鐵是細(xì)胞生長增殖、代謝的必需元素,轉(zhuǎn)鐵蛋白受體(TfR)介導(dǎo)的胞吞作用是細(xì)胞攝取鐵的主要途徑。腫瘤細(xì)胞因增殖生長旺盛,對鐵的需求高,所以腫瘤細(xì)胞有比正常細(xì)胞更多的轉(zhuǎn)鐵蛋白受體的表達(dá)。 |
