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Rabbit Anti-EDNRA  antibody (bs-1757R)  
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產(chǎn)品編號 bs-1757R
英文名稱 Rabbit Anti-EDNRA  antibody
中文名稱 內(nèi)皮素受體A抗體
別    名 Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothelin 1 specific receptor; Endothelin ET A receptor; Endothelin receptor ET1 specific type; Endothelin-1 receptor.  
Specific References  (3)     |     bs-1757R has been referenced in 3 publications.
[IF=2.197] Cheng P et al. Xin-Ji-Er-Kang Alleviates Myocardial Infarction-Induced Cardiovascular Remodeling in Rats by Inhibiting Endothelial Dysfunction. Biomed Res Int. 2019 Jun 25;2019:4794082.  IHF&WB ;  Rat.  
[IF=1.564] Haizhao Zhao. et al. The Influence of Bosentan on MicroRNA-27a/PPARγ/ET-1 Signaling Pathway in Pulmonary Artery Hypertension. 2021 Apr 15  WB ;  Human.  
[IF=0.939] Prayitnaningsih et al. Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats. (2016) Int.J.Ophthalmol. 9:1568-1577  IF(IHC-P) ;  Rat.  
研究領(lǐng)域 心血管  免疫學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 47kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EDNRA: 321-427/427 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subunit:
Interacts with HDAC7 and KAT5.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

SWISS:
P25101

Gene ID:
1909

Database links:

Entrez Gene: 281749 Cow

Entrez Gene: 450187 Dog

Entrez Gene: 1909 Human

Entrez Gene: 13617 Mouse

Entrez Gene: 397457 Pig

Entrez Gene: 24326 Rat

GenBank: NM_001957 Human

GenBank: NM_174308 Human

GenBank: NM_012550 Rat

Omim: 131243 Human

SwissProt: P21450 Cow

SwissProt: Q5KSU9 Dog

SwissProt: P25101 Human

SwissProt: Q61614 Mouse

SwissProt: Q29010 Pig

SwissProt: P26684 Rat

Unigene: 183713 Human

Unigene: 283168 Mouse

Unigene: 392296 Mouse

Unigene: 10915 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-EDNRA (bs-1757R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa
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