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Rabbit Anti-GDF9  antibody (bs-1795R)  
~~~促銷(xiāo)代碼KT202411~~~
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-1795R
英文名稱(chēng) Rabbit Anti-GDF9  antibody
中文名稱(chēng) 生長(zhǎng)分化因子9抗體
別    名 GDF9; GDF-9; GDF 9; GDF9_HUMAN; Growth differentiation factor 9.  
Specific References  (2)     |     bs-1795R has been referenced in 2 publications.
[IF=2.81] Zhang et al. Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles. (2016) PLoS.On. 11:e0151062  IHC-P ;  Mouse.  
[IF=2.586] G?k?e Nur Ar?k. et al. Melatonin effective to reduce the microscopic symptoms of polycystic ovary syndrome-related infertility: An experimental study. TISSUE CELL. 2023 Jan;:102015  IHC,WB ;  Rat.  
研究領(lǐng)域 心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  生長(zhǎng)因子和激素  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 15kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GDF-9: 351-452/452 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily. [provided by RefSeq, Jul 2008]

Function:
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

Subunit:
Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).

Subcellular Location:
Secreted (By similarity).

Tissue Specificity:
Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).

Post-translational modifications:
Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325.

DISEASE:
Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.

Similarity:
Belongs to the TGF-beta family.

SWISS:
O60383

Gene ID:
2661

Database links:

Entrez Gene: 2661 Human

GenBank: NP_005251 Human

Omim: 601918 Human

SwissProt: O60383 Human

SwissProt: Q4VAW5 Human

Unigene: 25022 Human



GDF9屬于轉(zhuǎn)移生長(zhǎng)因子–β(TGF-β)及骨形態(tài)發(fā)生蛋白(BMP)家族成員。
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