吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
疯狂的交换小雅小姿1~6,亚洲AV无码乱码在线观看性色
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-NAV1.7  antibody (bs-2427R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-2427R
英文名稱 Rabbit Anti-NAV1.7  antibody
中文名稱 電壓開啟的鈉離子通道SCN9A抗體
別    名 SCN9A; Sodium channel protein type 9 subunit alpha; ETHA; hNE Na; hNENa; NE NA; NENA; NE-NA; Neuroendocrine sodium channel; Peripheral sodium channel 1; PN1; SCN9A; Sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel voltage gated type IX alpha; Sodium channel voltage gated type IX alpha polypeptide; Sodium channel voltage gated type IX alpha subunit; Voltage gated sodium channel alpha subunit Nav1.7; Voltage gated sodium channel subunit alpha Nav1; FEB3B; SCN9A_HUMAN.  
Specific References  (1)     |     bs-2427R has been referenced in 1 publications.
[IF=2.456] Lijun Cheng. et al. Effects of ticagrelor pretreatment on electrophysiological properties of stellate ganglion neurons following myocardial infarction. Clin Exp Pharmacol P. 2020 Dec;47(12):1932-1942  IHC ;  Rabbit.  
研究領(lǐng)域 通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 219kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN9A: 451-550/1988 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]

Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.

Subunit:
The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L.

Subcellular Location:
Membrane; Multi-pass membrane protein. Note=In neurite terminals.

Tissue Specificity:
Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.

Post-translational modifications:
Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.

DISEASE:
Defects in SCN9A are the cause of primary erythermalgia (PERYTHM) [MIM:133020]. It is an autosomal dominant disease characterized by recurrent episodes of severe pain associated with redness and warmth in the feet or hands.
Defects in SCN9A are the cause of congenital indifference to pain autosomal recessive (CIPAR) [MIM:243000]; also known as channelopathy-associated insensitivity to pain. A disorder characterized by congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating.
Defects in SCN9A are a cause of paroxysmal extreme pain disorder (PEPD) [MIM:167400]; previously known as familial rectal pain (FRP). PEPD is an autosomal dominant paroxysmal disorder of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as skin flushing.
Defects in SCN9A are a cause of generalized epilepsy with febrile seizures plus type 7 (GEFS+7) [MIM:613863]. GEFS+7 is a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
Defects in SCN9A are the cause of familial febrile convulsions type 3B (FEB3B) [MIM:613863]. FEB3B consists of seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.

Similarity:
Belongs to the sodium channel (TC 1.A.1.10) family.

SWISS:
Q15858

Gene ID:
6335

Database links:

Entrez Gene: 6335 Human

Entrez Gene: 20274 Mouse

Entrez Gene: 78956 Rat

Omim: 603415 Human

SwissProt: Q15858 Human

SwissProt: Q62205 Mouse

SwissProt: O08562 Rat

Unigene: 439145 Human

Unigene: 440889 Mouse

Unigene: 88082 Rat



SCN9A是電壓門控鈉離子通道α-亞單位第Ⅸ型蛋白,是一種特殊的與疼痛有關(guān)的蛋白質(zhì),SCN9在機(jī)體中對(duì)鈉離子進(jìn)入細(xì)胞以及神經(jīng)元之間的交流起導(dǎo)向作用。這種蛋白集中在痛覺神經(jīng)的末梢,當(dāng)人受到疼痛刺激時(shí),這一蛋白質(zhì)會(huì)釋放鈉離子流,放大和刺激神經(jīng)細(xì)胞,將電子信號(hào)發(fā)送到大腦,從而使人們感覺到疼痛。
產(chǎn)品圖片
Sample: A549 Cell (Human) Lysate at 30 ug Primary: Anti-NAV1.7 (Bs- 2427R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 219 kD Observed band size: 219 kD
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久久久亚洲AV无码A片下载| 香港三日本8A三级少妇三级99| 婷婷人人爽人人爽人人片| 无码人妻精品一区二区三区9厂| 国产日韩欧美一区二区东京热| 国精产品一码二码三M| 窝窝午夜精品一区二区| 午夜精品一区二区三区在线观看| 国产一区二区三区精品视频| 久久午夜夜伦鲁鲁片无码免费| 色一情一乱一伦一区二区三区日本| 午夜时刻免费入口| 老熟女毛茸茸浓毛| 亚洲欧美日韩一区二区| 99国产精品久久久久久久成人热 | 迈开腿让我看看你的草莓| 欧美性猛交XXXX免费看| 扒开腿挺进湿润的花苞| 国产精品久久久久精品三级卜| 无码人妻精品一二三区免费| 久久久国产一区二区三区四区小说| 公与淑婷厨房猛烈进出视频| 2022最新韩国理伦片在线观看 | 性做久久久久久久久| 久久久精品中文字幕麻豆发布| 国产女人AAA级久久久级| 国产伦理一区二区| 亚洲成熟丰满熟妇高潮xxxxx| 麻花传媒剧国产MV网站| 国产亚洲成AV人片在线观黄桃| you jizz jizz japan日本| 人妻巨大乳一二三区| 男人J桶进女人P无遮挡全过程| 波多野结衣电影| 人妻含泪让粗大挺进| 日韩精品一区二区三区在线观看| 免费观看少妇全黄A片| 俄罗斯大荫蒂女人毛茸茸| 色一情一乱一乱一区99AV| 学长别揉了我快尿了男男| 亚洲国产成人精品无码区花野真一 |