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Rabbit Anti-Claudin 3  antibody (bs-2788R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號(hào) bs-2788R
英文名稱 Rabbit Anti-Claudin 3  antibody
中文名稱 緊密連接蛋白3抗體
別    名 C7orf1; Claudin3; Claudin-3; CLDN 3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; CLD3_HUMAN; CPE-receptor 2; Rat ventral prostate.1 protein homolog; RVP 1; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog.  
Specific References  (8)     |     bs-2788R has been referenced in 8 publications.
[IF=6.823] Caijun Zhao. et al. Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice. Plos Pathog. 2021 Jul;17(7):e1009774  WB ;  Mouse.  
[IF=5.265] Li, Ke. et al. The Prevention Effect of Lactobacillus plantarum 17–5 on Escherichia coli-Induced Mastitis in Mice. PROBIOTICS ANTIMICRO. 2023 Feb;:1-9  IF,WB ;  Mouse.  
[IF=4.034] Fuqing Huang. et al. Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. J Dairy Sci. 2022 Feb;:  WB ;  Mouse.  
[IF=3.829] Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11  WB ;  Pig.  
[IF=3.531] Yanan Gao. et al. Aflatoxin B1 and Aflatoxin M1 Induce Compromised Intestinal Integrity through Clathrin-Mediated Endocytosis. Toxins. 2021 Mar;13(3):184  WB,IF ;  Mouse, Human.  
[IF=3.392] Han L et al. Beneficial Effects of Potentilla discolor Bunge Water Extract on Inflammatory Cytokines Release and Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice.Nutrients.?2019 Mar 20;11(3).  WB ;  Mouse.  
[IF=2.46] Pan, Li, et al. "Effects of Soybean Agglutinin on Mechanical Barrier Function and Tight Junction Protein Expression in Intestinal Epithelial Cells from Piglets." International Journal of Molecular Sciences 14.11 (2013): 21689-21704.  Pig.  
[IF=1.607] Zhao B et al. N‐Acetyl‐d‐galactosamine prevents soya bean agglutinin‐induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Apr 1.  WB ;  Porcine.  
研究領(lǐng)域 腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 23kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CLDN3: 51-150/220 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

DISEASE:
Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Similarity:
Belongs to the claudin family.

SWISS:
O15551

Gene ID:
1365

Database links:

Entrez Gene: 1365 Human

Entrez Gene: 12739 Mouse

Entrez Gene: 65130 Rat

Omim: 602910 Human

SwissProt: O15551 Human

SwissProt: Q9Z0G9 Mouse

SwissProt: Q63400 Rat

Unigene: 647023 Human

Unigene: 158662 Mouse

Unigene: 4513 Rat



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