| 產(chǎn)品編號 | bs-2888R |
| 英文名稱 | Rabbit Anti-TRPM2 antibody |
| 中文名稱 | 瞬時受體電位離子通道蛋白/M亞家族抗體 |
| 別 名 | EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7. |
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Specific References (2) | bs-2888R has been referenced in 2 publications.
[IF=7.525] Li, Xiangji. et al. The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels. CELL COMMUN SIGNAL. 2022 Dec;20(1):1-15 IHC, WB ; Human.
[IF=4.081] Y?ld?zhan, Kenan. et al. Involvement of TRPM2 Channel on Doxorubicin-Induced Experimental Cardiotoxicity Model: Protective Role of Selenium. BIOL TRACE ELEM RES. 2022 Aug;:1-12 IHC ; Rat.
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| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:2000-5000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 165kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRPM2: 951-1050/1503 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. Contains 1 nudix hydrolase domain. SWISS: O94759 Gene ID: 7226 Database links: Entrez Gene: 7226 Human Entrez Gene: 28240 Mouse Omim: 603749 Human SwissProt: O94759 Human SwissProt: Q5KTC0 Mouse SwissProt: Q91YD4 Mouse Unigene: 369759 Human Unigene: 276762 Mouse Unigene: 214495 Rat TRPM2 屬于瞬時受體電位離子通道蛋白家族的M亞家族，是一種非選擇性的陽離子通道蛋白, 是離子通道蛋白參與了單核細胞的氧化應(yīng)激應(yīng)答反應(yīng)，與老年性癡呆等神經(jīng)退行疾病的發(fā)生與發(fā)展有著十分密切的聯(lián)系. |
