吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
色一情一区二,凹凸久久人人澡超碰凹凸,男JI大巴进入女人的视频
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-CACNA1C  antibody (bs-2806R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2806R
英文名稱 Rabbit Anti-CACNA1C  antibody
中文名稱 L-型電壓依賴型鈣通道α抗體
別    名 alpha-1 polypeptide; cardiac muscle; isoform 1; L type; CAC1C_HUMAN; CACH 2; DHPR alpha 1; VDCC-L alpha; CACH2; CACN 2; CACN2; Calcium channel; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle; Calcium channel voltage dependent L type alpha 1C subunit; CaV1.2; CCHL1A1; DHPR alpha 1 subunit; LQT8; TS; Voltage dependent L type calcium channel alpha 1C subunit; Voltage dependent L type calcium channel subunit alpha 1C; Voltage gated calcium channel alpha subunit Cav1.2; Voltage gated calcium channel subunit alpha Cav1.2; Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2.  
Specific References  (2)     |     bs-2806R has been referenced in 2 publications.
[IF=3.499] Zhan C et al. Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats. Toxicol Lett. 2019 Oct 1. pii: S0378-4274(19)30295-4.  IHC-P ;  Rat.  
[IF=3.2] Lobeck, Inna, et al. "Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes." Virology 499 (2016): 185-195.  IF(ICC) ;  Mouse.  
研究領(lǐng)域 心血管  免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 249kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DHPR alpha 1: 1001-1100/2221 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq]

Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subunit:
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4. Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane. Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Tissue Specificity:
Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

Post-translational modifications:
Phosphorylation by PKA activates the channel.

DISEASE:
Defects in CACNA1C are the cause of Timothy syndrome (TS) [MIM:601005]. TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.
Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3) [MIM:611875]. A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.

SWISS:
Q13936

Gene ID:
775

Database links:

Entrez Gene: 775 Human

Entrez Gene: 12288 Mouse

Entrez Gene: 100144322 Rabbit

Entrez Gene: 24239 Rat

Omim: 114205 Human

SwissProt: Q13936 Human

SwissProt: Q01815 Mouse

SwissProt: P15381 Rabbit

SwissProt: P22002 Rat

Unigene: 118262 Human

Unigene: 436656 Mouse

Unigene: 9827 Rat



L型鈣通道廣泛分布于心肌細(xì)胞膜上,尤其T管上含量最為豐富,是心肌細(xì)胞膜的主要鈣通道類型。L型鈣通道的開閉主要受膜電位變化的影響,是電壓依賴性鈣通道,激活電位-40~-30mV,失活電位-20mV。L型鈣通道開放后持續(xù)的時(shí)間長較長,激活占時(shí)20~30ms,失活更慢(100~300ms),又稱為慢鈣通道。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
又粗又大内射免费视频小说| 人妻VA精品VA欧美VA| 国产精品欧美一区二区三区| 国产精品无码无卡无需播放器| 亚洲AV永久无码精品三区在线| 国产精品宅男擼66M3U8| 亚洲精品无码午夜福利中文字幕 | 疯狂的交换小雅小姿1~6| 夜里十大禁用直播APP| 一边摸一边抽搐一进一出| 国产+高潮+白浆+无码| 一本久道中文无码字幕AV| 亚洲AV无码国产综合专区| 久久综合伊人77777麻豆| 又爆又大又粗又硬又黄的A片| 亚洲AV无码成H在线观看| FREE性中国熟女HD| 最新精品国偷自产在线69| 在线观看免费人成视频| 无码精品人妻一区二区三区AV | 黄页网站推广APP天堂| 斗罗大陆在线全集免费看| 甜蜜惩罚我是看守专用宠物| 色多多app| 久久精品国产亚洲av高清热| 亚洲精品国产精品国自产观看| 成人性爱视频在线观看| 多毛熟女HDVIDOS| 欧美日本免费一区二区三区| 欧美无人区码SUV| 成人做爰免费视频免费看| 99精品欧美一区二区三区| 性国产SE╳O色欲A片欢迎观看| 国产成人AV| 苍井空亚洲精品AA片在线播放| 国产在线视频一区二区三区| 特级AAAAAAAAA毛片免费视频| 亚洲精品乱码久久久久久蜜桃不卡| 国产在线精品二区| 国产自拍AV| 玩小雪跪趴把腿分到最大影视|