吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
色一情一区二,国产女人18毛片水真多1
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-Phospho-CRTC1 (Ser151)  antibody (bs-3453R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-3453R
英文名稱 Rabbit Anti-Phospho-CRTC1 (Ser151)  antibody
中文名稱 磷酸化CREB轉錄共激
別    名 CRTC1_HUMAN; CREB-regulated transcription coactivator 1; CREB regulated transcription coactivator 1; KIAA0616; MECT1; TORC1; WAMTP1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1 (TORC-1; Transducer of CREB protein 1);   
Specific References  (1)     |     bs-3453R has been referenced in 1 publications.
[IF=7.65] Wang Y et al. Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress。 Journal of Hazardous Materials. 2019 Sep.  WB ;  Chicken.  
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  神經(jīng)生物學  信號轉導  轉錄調節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,Flow-Cyt=1μg /Test,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 70kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151: TN(p-S)DS 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Subunit:
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.

Tissue Specificity:
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Post-translational modifications:
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR

DISEASE:
Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Similarity:
Belongs to the TORC family.

SWISS:
Q6UUV9

Gene ID:
23373

Database links:

Entrez Gene: 23373?/span>Human

Entrez Gene: 382056?/span>Mouse

Entrez Gene: 684527?/span>Rat

Omim: 607536?/span>Human

SwissProt: Q6UUV9?/span>Human

SwissProt: Q68ED7?/span>Mouse

SwissProt: Q157S1?/span>Rat

Unigene: 371096?/span>Human

Unigene: 428214?/span>Human

Unigene: 227767?/span>Mouse

Unigene: 208248?/span>Rat



產(chǎn)品圖片
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Phospho-Torc1(Ser151) Polyclonal Antibody, Unconjugated(bs-3453R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human brain glioma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Phospho-Torc1(Ser151) Polyclonal Antibody, Unconjugated(bs-3453R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control(black line):K562. Primary Antibody (green line): Rabbit Anti-Phospho-CRTC1 (Ser151) antibody (bs-3453R) Dilution:1ug/Test; Secondary Antibody(white blue line): Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control(orange line): Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃, The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
Positive control: Hela cells Concebtration: 5μg/10^6 cells Incubation conditions: Avoid light , 30 minutes on the ice.
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品午夜福利在线观看| 天天爱天天做天天爽| 国产丰满老熟女重口对白| 天天做天天爱天天爽综合网 | 精品无码国产一区二区三区麻豆| 国产SM主人调教女M视频| 大肥波BBWWHBBWW| 久久久亚洲精品无码| 日本免费一区二区三区高清视频| 丁香花在线观看免费观看图片| 国产99久一区二区三区A片| 国产精品久久久久久久久久妞妞| 激情综合婷婷色五月蜜桃| 娇小videodes极品| 欧美精品一区二区少妇免费A片| 蜜臀AV在线播放一区二区三区 | 国产精品视频一区二区三区不卡| 国产中年熟女高潮大集合| 日韩AV无码中文字幕| 欧美成人片一区二区三区| 成人视频在线观看| 一边吃奶一边添P好爽故事 | 国产免费AV| 亚洲av激情无码专区在线播放| 波多野结衣绝顶大高潮| 麻花传媒剧国产MV网站| 精品少妇人妻AV免费久久洗澡| 18禁白丝喷水视频WWW视频| 国产偷窥盗拍丰满老熟女| 狠狠综合久久AV一区二区 | 国产婷婷色一区二区三区在线| 日本动漫在线| 久久久久久国产精品免费免费男同| 日产精品高潮呻吟AV久久| 色七七影院| 国产精品成人无码免费| 亂倫近親相姦中文字幕| 精品欧美一区二区三区久久久| 国产999精品久久久久久| 裸身美女无遮挡永久免费视频| 高清VPSWINDOWS另类乱|