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Rabbit Anti-ABCG5  antibody (bs-5013R)  
~~~促銷代碼KT202411~~~
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-5013R
英文名稱 Rabbit Anti-ABCG5  antibody
中文名稱 三磷酸腺苷結(jié)合轉(zhuǎn)運蛋白G超家族成員5抗體
別    名 ABCG5_HUMAN; ATP binding cassette sub family G (WHITE) member 5 (sterolin 1); ATP binding cassette sub family G member 5; ATP-binding cassette sub-family G member 5; Sterolin 1; Sterolin-1; STSL.  
Specific References  (9)     |     bs-5013R has been referenced in 9 publications.
[IF=5.08] Zhong, Chun-Yan, et al. "Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice." Scientific Reports 5 (2015).  WB ;  Mouse.  
[IF=4.879] Jean Baptiste Nyandwi. et al. Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice. Biomolecules. 2021 Oct;11(10):1470  WB ;  Mouse.  
[IF=3.97] Ding, Lin, et al. "Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism." Journal of Functional Foods 32 (2017): 90-97.  WB ;  Mouse.  
[IF=3.241] Zhang L et al. Eicosapentaenoic acid in the form of phospholipid exerts superior anti-atherosclerosis effects than its triglyceride form in ApoE-/-mice. Food & Function. 2019  WB ;  Mouse.  
[IF=3.12] Yan R et al. PM2. 5 exposure induces age-dependent hepatic lipid metabolism disorder in female mice. journal of environmental science.2019.  WB ;  Mouse.  
[IF=2.66] Gao et al. Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats. (2013) Lipids.Health.Dis. 12:118  WB ;  Rat.  
[IF=2.65] Huiming Hu. et al. The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats.. EVID-BASED COMPL ALT. 2022 Nov;2022:3033311-3033311  WB ;  Rat.  
[IF=2.02] Wang, Shuling, et al. "Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats." Lipids in Health and Disease 13.1 (2014): 77.  WB ;  Rat.  
[IF=1.41] Huang et al. Effects of mulberry leaf on experimental hyperlipidemia rats induced by high-fat diet. (2018) Exp.Ther.Med. 16:547-556  WB ;  Rat.  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  轉(zhuǎn)運蛋白  結(jié)合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 72kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABCG5: 251-350/651 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].

Function:
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subunit:
May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.

Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).

Tissue Specificity:
Strongly expressed in the liver, lower levels in the small intestine and colon.

DISEASE:
Defects in ABCG5 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.

Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.

SWISS:
Q9H222

Gene ID:
64240

Database links:

Entrez Gene: 64240 Human

Omim: 605459 Human

SwissProt: Q9H222 Human

Unigene: 132992 Human



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