| 產(chǎn)品編號 | bs-4174R |
| 英文名稱 | Rabbit Anti-SIRT6 antibody |
| 中文名稱 | 沉默調(diào)節(jié)相關(guān)蛋白6抗體 |
| 別 名 | NAD-dependent protein deacylase sirtuin-6; SIR2L6; EC:2.3.1.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIR6_HUMAN; |
| 研究領(lǐng)域 | 腫瘤 心血管 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 新陳代謝 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 39kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SIRT6: 121-220/355 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Subunit: Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Subcellular Location: Nucleus, nucleoplasm. Similarity: Belongs to the sirtuin family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain. SWISS: Q8N6T7 Gene ID: 51548 Database links: Entrez Gene: 51548 Human Entrez Gene: 50721 Mouse SwissProt: Q8N6T7 Human SwissProt: P59941 Mouse SIRT6是一種酶，能夠從組蛋白的一個特定位點上移走稱之為乙?；M的化學(xué)物質(zhì)。組蛋白對調(diào)控基因表達(dá)非常重要，而從組蛋白中移除乙?；M就會“關(guān)閉”某些基因表達(dá)。 SIRT6蛋白與NF-kappaB（NF-kB）一同，可以調(diào)節(jié)凋亡、炎癥和新陳代謝相關(guān)基因的作用。當(dāng)減少SIRT6時，NF-kappaB變得過度活躍，開啟同衰老相關(guān)的基因。 |
