| 產(chǎn)品編號(hào) | bs-4566R |
| 英文名稱 | Rabbit Anti-SPRN antibody |
| 中文名稱 | 新朊蛋白抗體（C端） |
| 別 名 | rCG47959; shadow of prion protein; SHO; Protein shadoo; bA108K14.1; C630041J07; FLJ41197; SPRN; Shadow of prion protein precursor; SPRN_MOUSE. |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 12kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse Shadow: 81-147/147 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Constitutively expressed in normal adult brain, cellular PrP (PrP(C)) is sensitive to proteinase K digestion and is converted to the disease form, PrPSc, through alterations in protein folding conformation, which make it resistant proteases. SPRN (shadow of prion protein), also known as SHO or SHADOO, is a 151 amino acid cytoplasmic protein that is mainly expressed in brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and may act as a modulator for the biological actions of normal and abnormal PrP. In humans, mutations in the gene encoding SPRN may be associated with variant and sporadic Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably fatal. Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Mainly expressed in brain (at protein level). In brain, it is highly expressed in the hippocampus and cerebellum and is also expressed at lower level in other areas of the brain including the cerebral cortex, the thalamus and the medulla. In hippocampus and cerebellum it is highly expressed in the cell bodies of pyramidal cells and Purkinje cells, respectively. Post-translational modifications: N-glycosylated. Similarity: Belongs to the SPRN family. SWISS: Q8BWU1 Gene ID: 212518 Database links: Entrez Gene: 503542 Human Entrez Gene: 212518 Mouse Omim: 610447 Human SwissProt: Q5BIV9 Human SwissProt: Q8BWU1 Mouse 朊病毒蛋白（朊蛋白相關(guān)蛋白、沙杜蛋白）是導(dǎo)致動(dòng)物腦細(xì)胞死亡的傳染性病毒蛋白，是一種致病性神經(jīng)蛋白。 朊蛋白相關(guān)蛋白Shadoo是近期才被發(fā)行的新朊蛋白，其傳播、傳染過(guò)程尚不清楚，發(fā)病機(jī)理還有待于研究中。 |
