| 產(chǎn)品編號(hào) | bs-5846R |
| 英文名稱 | Rabbit Anti-ADAM11 antibody |
| 中文名稱 | 去整合素樣金屬蛋白酶11抗體 |
| 別 名 | A disintegrin and metalloproteinase domain 11; ADA11_HUMAN; MDC; Metalloproteinase like, disintegrin like, and cysteine rich protein. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞骨架 細(xì)胞外基質(zhì) 泛素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 60kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADAM11: 351-450/769 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]. Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Subunit: Can bind to LGI1 and LGI4. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues. Post-translational modifications: The precursor is cleaved by a furin endopeptidase. Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. SWISS: O75078 Gene ID: 4185 Database links: Entrez Gene: 4185 Human Omim: 155120 Human SwissProt: O75078 Human Unigene: 6088 Human 細(xì)胞外基質(zhì)蛋白 |
| 產(chǎn)品圖片 |
Sample: A549 Cell (Human) Lysate at 40 ug
Primary: Anti-ADAM11 (bs-5846R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60 kD
Observed band size: 60 kD
Sample:
brain (Mouse) Lysate at 40 ug
Primary: Anti-ADAM11 (bs-5846R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60 kD
Observed band size: 60 kD
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