| 產(chǎn)品編號(hào) | bs-5857R |
| 英文名稱 | Rabbit Anti-ADAMTS15 antibody |
| 中文名稱 | 整合素樣金屬蛋白酶與凝血酶15型抗體 |
| 別 名 | A disintegrin and metalloproteinase with thrombospondin motifs 15; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15; A disintegrin like and metalloprotease Reprolysin type with thrombospondin type 1 motif 15 preproprotein; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein; ADAM metallopeptidase with thrombospondin type 1 motif 15; ADAM TS 15; ADAM TS15; ADAMTS 15; ATS15_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 103kDa |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADAMTS15: 141-240/950 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Subcellular Location: Secreted, extracellular space, extracellular matrix (By similarity). Tissue Specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues examined. Post-translational modifications: The precursor is cleaved by a furin endopeptidase (By similarity). Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 3 TSP type-1 domains. SWISS: Q8TE58 Gene ID: 170689 Database links: Entrez Gene: 170689 Human Entrez Gene: 235130 Mouse Omim: 607509 Human SwissProt: Q8TE58 Human SwissProt: P59384 Mouse SwissProt: Q504Z2 Mouse Unigene: 534221 Human Unigene: 65867 Mouse 細(xì)胞外基質(zhì)蛋白 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Embryo tissue lysates
Lane 2: Mouse Placenta tissue lysates
Lane 3: Mouse Heart tissue lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human 293T cell lysates
Primary: Anti-ADAMTS15 (bs-5857R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 103 kDa
Observed band size: 100 kDa
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