| 產(chǎn)品編號 | bs-6049R |
| 英文名稱 | Rabbit Anti-FGFR5 antibody |
| 中文名稱 | 成纖維細(xì)胞生長因子受體5抗體 |
| 別 名 | FGF homologous factor receptor; FGF receptor like protein 1; FGFR 5; FGFR like protein; FGFR5; FGFRL1; FHFR; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor like 1; FGRL1_HUMAN. |
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Specific References (3) | bs-6049R has been referenced in 3 publications.
[IF=6.205] Cheng S et al. Comparative analysis of Longissimus dorsi tissue from two sheep groups identifies differentially expressed genes related to growth, development and meat quality. Genomics. 2020 Sep;112(5):3322-3330. WB ; Sheep.
[IF=5.78] Xiongjie Fu. et al. Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice. 2021 Feb 04 IF ; Mouse.
[IF=4.486] Wang L et al. Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. J Cell Mol Med. 2020 Jun;24(11):6324-6339. WB ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 52kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGFR5/FGFRL1: 231-330/504 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found. Function: UniProtKB/Swiss-Prot: Q8N441.1 FASTA Graphics Go to: LOCUS FGRL1_HUMAN 504 aa linear PRI 01-MAY-2013 DEFINITION RecName: Full=Fibroblast growth factor receptor-like 1; Short=FGF receptor-like protein 1; AltName: Full=FGF homologous factor receptor; AltName: Full=FGFR-like protein; AltName: Full=Fibroblast growth factor receptor 5; Short=FGFR-5; Flags: Precursor. Subunit: Interacts with FGF2 with a low affinity. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q8N441 Gene ID: 53834 Database links: Entrez Gene: 53834 Human Entrez Gene: 116701 Mouse Omim: 605830 Human SwissProt: Q8N441 Human SwissProt: Q91V87 Mouse Unigene: 193326 Human Unigene: 35691 Mouse Unigene: 44953 Rat |
