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Rabbit Anti-EMP2  antibody (bs-6264R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-6264R
英文名稱 Rabbit Anti-EMP2  antibody
中文名稱 上皮細胞膜蛋白2抗體
別    名 EMP-2; EMP2; EMP2_HUMAN; Epithelial membrane protein 2; Protein XMP.  
Specific References  (2)     |     bs-6264R has been referenced in 2 publications.
[IF=7.273] Torella D et al. MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus.(2018) Diabetes. Sep 26  IF ;  Rat.  
[IF=3.117] Pan, Jian. et al. miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization. 2021 Sep 08  WB ;  human,rat.  
研究領域 腫瘤  發(fā)育生物學  信號轉導  激酶和磷酸酶  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EMP2: 65-167/167 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 EMP-2 is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the PMP-22/EMP/MP20 family.

SWISS:
P54851

Gene ID:
2013

Database links:

Entrez Gene: 2013 Human

Entrez Gene: 13731 Mouse

Omim: 602334 Human

SwissProt: P54851 Human

SwissProt: O88662 Mouse

Unigene: 531561 Human

Unigene: 246009 Mouse



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