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Rabbit Anti-FTO  antibody (bs-7056R)  
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產(chǎn)品編號 bs-7056R
英文名稱 Rabbit Anti-FTO  antibody
中文名稱 脂肪堆積和肥胖相關(guān)蛋白抗體
別    名 Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; FTO_HUMAN; Protein fatso.  
Specific References  (8)     |     bs-7056R has been referenced in 8 publications.
[IF=11.161] Cui Yuanbo. et al. RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma. J Exp Clin Canc Res. 2021 Dec;40(1):1-20  WB ;  human.  
[IF=6.376] Wang, Xiaoying. et al. LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation. MOL MED. 2022 Dec;28(1):1-20  WB ;  Human.  
[IF=6.291] Leqiang Gao. et al. Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder. ECOTOX ENVIRON SAFE. 2022 Jun;237:113534  WB ;  Rat.  
[IF=5.714] Xuhua Sun. et al. Identification of clinical heterogeneity and construction of a novel subtype predictive model in patients with ankylosing spondylitis: An unsupervised machine learning study. INT IMMUNOPHARMACOL. 2023 Apr;117:109879  IHC ;  Human.  
[IF=3.628] Yuanchao Ling. et al. Bisphenol A exposure induces testicular oxidative damage via FTO/m6A/Nrf2 axis during postnatal development in mice. J APPL TOXICOL. 2022 Nov;:  WB ;  Mouse.  
[IF=3.569] Tengjiao Qu. et al. Changes and relationship of N6-methyladenosine modification and long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells. Toxicol Lett. 2021 Jun;343:56  WB ;  Mouse.  
[IF=3.337] Jun Zhang. et al. To Develop and Validate the Combination of RNA Methylation Regulators for the Prognosis of Patients with Gastric Cancer. Oncotargets Ther. 2020; 13: 10785–10795  IHC ;  Human.  
[IF=3.231] Jiaojiao Yang. et al. FTO Regulates Apoptosis in CPB2-Treated IPEC-J2 Cells by Targeting Caspase 3 Apoptotic Protein. ANIMALS. 2022 Jan;12(13):1644  WB ;  Pig.  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 58kDa
檢測分子量 58
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Protein fatso: 165-265/505 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Tissue specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.

Function:
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.

Subunit:
Monomer. May also exist as homodimer.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.

DISEASE:
Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:612938]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.

Similarity:
Belongs to the fto family.

SWISS:
Q9C0B1

Gene ID:
79068

Database links:

Entrez Gene: 79068?Human

Entrez Gene: 26383?Mouse

Entrez Gene: 291905?Rat

Omim: 610966?Human

SwissProt: Q9C0B1?Human

SwissProt: Q8BGW1?Mouse

SwissProt: Q2A121?Rat

產(chǎn)品圖片
Sample: Lane 1: Mouse Adrenal gland tissue lysates Lane 2: Rat Adrenal gland tissue lysates Lane 3: Human SH-SY5Y cell lysates Lane 4: Human HeLa cell lysates Lane 5: Human U87MG cell lysates Lane 6: Human MOLT4 cell lysates Primary: Anti-FTO (bs-7056R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kDa Observed band size: 60 kDa
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