| 產(chǎn)品編號 | bs-7658R |
| 英文名稱 | Rabbit Anti-CTNNBL1 antibody |
| 中文名稱 | β連環(huán)蛋白樣蛋白1抗體 |
| 別 名 | Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNNBL 1; Ctnnbl1; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; P14 antibody P14L; Testis development protein NYD SP19; Testis development protein NYD-SP19. |
| 研究領(lǐng)域 | 細胞生物 染色質(zhì)和核信號 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 65kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CTNNBL1/Beta catenin like 1: 381-480/563 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. Subunit: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid. SWISS: Q8WYA6 Gene ID: 56259 Database links: Entrez Gene: 56259 Human Entrez Gene: 66642 Mouse Omim: 611537 Human SwissProt: Q8WYA6 Human SwissProt: Q9CWL8 Mouse Unigene: 472667 Human Unigene: 45193 Mouse Unigene: 98091 Rat |
