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Rabbit Anti-LRFN4  antibody (bs-11089R)  
~~~促銷代碼KT202411~~~
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200ul/2800.00元
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產品編號 bs-11089R
英文名稱 Rabbit Anti-LRFN4  antibody
中文名稱 富含亮氨酸重復序列/Ⅲ型纖維連接蛋白4抗體
別    名 Alternative namesFIGLER6; leucine rich repeat and fibronectin type III domain containing 4; fibronectin type III, immunoglobulin and leucine rich repeat domains 6; Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Lrfn4; LRFN4_HUMAN; MGC3103; SALM3.  
研究領域 神經生物學  信號轉導  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog)
產品應用 Flow-Cyt=0.2ug/test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 65kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LRFN4: 21-120/635 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 LRFN4 is a 635 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing a fibronectin type-III domain, an Ig-like (immunoglobulin-like) domain, a LRRCT domain, a LRRNT domain and seven LRR (leucine-rich) repeats, LRFN4 is thought to promote neurite outgrowth in hippocampal neurons and may play a role in redistributing PSD-95 to the cell periphery. LRFN4 forms heteromeric complexes with LRFN1, LRFN2, LFRN3 and LFRN5, but does not have the ability to form homomeric complexes across cell junctions of adjacent cells like some other LRFN family members. The PDZ-binding motif of LRFN4 is required for neurite outgrowth promotion and for SAP 97-, NE-dlg- and PSD-95-binding. LRFN4 is encoded by a gene located on human chromosome 11q13.1 and mouse chromosome 19 A.

Function:
Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery.

Subunit:
Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LRFN5. Unable to form homophilic interactions across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4.

Subcellular Location:
Membrane; Single-pass type I membrane protein (By similarity).

Post-translational modifications:
Glycosylated (By similarity).

Similarity:
Belongs to the LRFN family.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

SWISS:
Q6PJG9

Gene ID:
78999

Database links:

Entrez Gene: 78999 Human

Entrez Gene: 225875 Mouse

Entrez Gene: 688721 Rat

Omim: 612810 Human

SwissProt: Q6PJG9 Human

SwissProt: Q80XU8 Mouse

SwissProt: D4ABX8 Rat

Unigene: 209979 Human

Unigene: 714189 Human

Unigene: 329675 Mouse

Unigene: 198548 Rat



產品圖片
Blank control: Hela. Primary Antibody (green line): Rabbit Anti-LRFN4 antibody (bs-11089R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 0.2μg /test. Protocol The cells were incubated in 5 %BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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