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Rabbit Anti-NRXN2  antibody (bs-11104R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-11104R
英文名稱 Rabbit Anti-NRXN2  antibody
中文名稱 軸突蛋白2抗體
別    名 Neurexin 2; Neurexin-2; Neurexin2; Neurexin II; Neurexin II alpha; NRXN 2; NRXN-2; NRX2A_HUMAN.  
研究領(lǐng)域 神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞膜蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 182kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NRXN2: 971-1070/1712 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

Function:
Neurexin 2 alpha belongs to the Neurexin family, a group of neuronal proteins that function as cell adhesion molecules during synaptogenesis and intracellular signaling. Mammalian genomes contain just three neurexin genes. However, many neurexin isoforms may be expressed through the use of two alternative promoters and alternative splicing at up to five different positions.

Subunit:
The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL.

Subcellular Location:
Membrane; single-pass type I membrane protein.

Tissue Specificity:
Predominantly expressed in brain.

Similarity:
Belongs to the neurexin family.
Contains 3 EGF-like domains.
Contains 6 laminin G-like domains.

SWISS:
Q9P2S2

Gene ID:
9379

Database links:

Entrez Gene: 9379 Human

Entrez Gene: 18190 Mouse

Entrez Gene: 116595 Rat

SwissProt: Q9P2S2 Human

SwissProt: Q63374 Rat

Unigene: 372938 Human

Unigene: 329616 Mouse

Unigene: 414022 Mouse

Unigene: 11282 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Neurexin II alpha) Polyclonal Antibody, Unconjugated (bs-11104R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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