| 產(chǎn)品編號 | bs-11499R |
| 英文名稱 | Rabbit Anti-ARMETL1 antibody |
| 中文名稱 | 腦多巴胺神經(jīng)營養(yǎng)因子抗體 |
| 別 名 | CDNF; Arginine rich mutated in early stage tumors like 1; ARMET L1; ARMET like protein 1; ARMET-like protein 1; ARMETL 1; Cdnf; CDNF_HUMAN; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARMETL1: 101-187/187 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CDNF is an ARMET family member that is known to be a trophic factor for dopamine neurons. CDNF has been shown to prevent the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF application will restore the dopaminergic function that is reduced by lesions formed from administering 6-OHDA. CDNF further prevents the degeneration of dopaminergic neurons in substantia nigra. CDNF is expressed at high levels in the heart, skeletal muscle, testis and brain. In brain, CDNF has selective expression with the highest being detected in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus. Function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Subcellular Location: Secreted. Tissue Specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. Similarity: Belongs to the ARMET family. SWISS: Q49AH0 Gene ID: 441549 Database links: Entrez Gene: 441549 Human Omim: 611233 Human SwissProt: Q49AH0 Human Unigene: 559067 Human |
