| 產(chǎn)品編號(hào) | bs-11502R |
| 英文名稱 | Rabbit Anti-NENF antibody |
| 中文名稱 | 神經(jīng)源性神經(jīng)營(yíng)養(yǎng)因子抗體 |
| 別 名 | Neudesin; Cell growth inhibiting protein 47; Cell immortalization-related protein 2; CIR2; Nenf; NENF_HUMAN; Neuron derived neurotrophic factor; Neuron-derived neurotrophic factor; SCIRP10; SCIRP10 related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF; SPUF protein. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16kDa |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neudesin: 51-140/172 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Neudesin is a 172 amino acid secreted protein that belongs to the cytochrome b5 family and MAPR subfamily. Neudesin possesses neurotrophic activity, which is enhanced by binding to heme, and may contribute to neuronal differentiation and neural cell proliferation. In primary cultured neurons, Neudesin has been observed to activate Akt1 and ERK 1 phosphorylation. Upregulated in immortal cells, Neudesin contains one cytochrome b5 heme-binding domain and is encoded by a gene that maps to human chromosome 1q32.3. Human chromosome 1 spans 260 million base pairs and comprises nearly 8% of the human genome. A large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome, map to chromosome 1. Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. Subcellular Location: Secreted > extracellular space. Similarity: Belongs to the cytochrome b5 family. MAPR subfamily. Contains 1 cytochrome b5 heme-binding domain. SWISS: Q9UMX5 Gene ID: 29937 Database links: Entrez Gene: 29937 Human Entrez Gene: 66208 Mouse Omim: 611874 Human SwissProt: Q9UMX5 Human SwissProt: Q9CQ45 Mouse Unigene: 461787 Human Unigene: 46444 Mouse Unigene: 3355 Rat |
