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Rabbit Anti-GGT6  antibody (bs-13350R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-13350R
英文名稱 Rabbit Anti-GGT6  antibody
中文名稱 γ-谷氨酰轉(zhuǎn)肽酶6抗體
別    名 Gamma glutamyltransferase 6 homolog; Gamma glutamyltranspeptidase 6; GGT 6.  
研究領(lǐng)域 細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GGT6: 351-450/493 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Gamma-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. Belonging to the gamma-glutamyltranspeptidase family, GGT6 (gamma-glutamyltransferase 6), is a 493 amino acid single-pass type II membrane protein that cleaves glutathione conjugates. GGT6 exists as two alternatively spliced isoforms.

Function:
GGT6 belongs to the gamma-glutamyltransferase family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis. GGT6 has very limited amino acid similarity to GGT1 and it's enzymatic activities are currently uncharacterized. GGT assays are of current widespread clinical use to help assess tissue damage.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

SWISS:
Q6P531

Gene ID:
124975

Database links:

Entrez Gene: 124975 Human

Omim: 612341 Human

SwissProt: Q6P531 Human

Unigene: 130749 Human



產(chǎn)品圖片
Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Rat Liver tissue lysates Lane 3: Human MCF-7 cell lysates Lane 4: Human HepG2 cell lysates Lane 5: Human A431 cell lysates Primary: Anti-GGT6 (bs-13350R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 60 kDa
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