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Rabbit Anti-GMIP  antibody (bs-13458R)  
~~~促銷代碼KT202411~~~
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-13458R
英文名稱 Rabbit Anti-GMIP  antibody
中文名稱 GEM相互作用蛋白抗體
別    名 ARHGAP46; GEM interacting protein.  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導  轉(zhuǎn)運蛋白  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Pig,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 107kDa
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GMIP: 51-150/970 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The Rho family of GTP-binding proteins plays a role in the development of neuronal structure. The activation of the GTP-bound form is regulated by GTPase-activating proteins, which stimulate GTP hydrolysis, leading to inactivation. GMIP (Gem-interacting protein) is a 970 amino acid protein that stimulates the GTPase activity of RhoA in vitro and in vivo. GMIP interacts with Gem through its N-terminus and has a Rho GTPase-activating protein domain at its C-terminus. GMIP is able to inhibit RhoA function, leading to Actin cytoskeletal reorganization in vivo. Encoded by a gene that maps to human chromosome 19p13.11, GMIP contains one phorbol-ester/DAG-type zinc finger and one Rho-GAP domain.

Function:
Stimulates, in vitro and in vivo, the GTPase activity of RhoA.

Subunit:
Interacts with GEM through its N-terminal.

Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Rho-GAP domain.

SWISS:
Q9P107

Gene ID:
51291

Database links:

Entrez Gene: 51291 Human

Omim: 609694 Human

SwissProt: Q9P107 Human

Unigene: 49427 Human



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