| 產(chǎn)品編號(hào) | bs-15562R |
| 英文名稱 | Rabbit Anti-IFT43 antibody |
| 中文名稱 | 細(xì)胞纖毛內(nèi)轉(zhuǎn)運(yùn)同源蛋白43抗體 |
| 別 名 | C14orf179; ift43; IFT43_HUMAN; Intraflagellar transport protein 43 homolog. |
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Specific References (1) | bs-15562R has been referenced in 1 publications.
[IF=2.985] Dong Dinget al. The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes. Biochem Biophys Res Commun
. 2020 Sep 10;530(1):167-172. WB ; mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFT43: 111-208/208 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
IFT43 is a gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Function: Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. Subunit: Component of the IFT complex A (IFT-A) complex (Probable). Interacts with WDR35/IFT121. Subcellular Location: Cytoplasm, cytoskeleton. Note=Associated with microtubules. DISEASE: Cranioectodermal dysplasia 3 (CED3) [MIM:614099]: A disorder primarily characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include craniosynostosis, narrow rib cage, short limbs, brachydactyly, hypoplastic and widely spaced teeth, sparse hair, skin laxity and abnormal nails. Nephronophthisis leading to progressive renal failure, hepatic fibrosis, heart defects, and retinitis pigmentosa have also been described. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the IFT43 family. SWISS: Q96FT9 Gene ID: 112752 Database links: Entrez Gene: 112752 Human Omim: 614068 Human SwissProt: Q96FT9 Human Unigene: 532626 Human |
