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Rabbit Anti-Rb2 p130  antibody (bs-4984R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-4984R
英文名稱 Rabbit Anti-Rb2 p130  antibody
中文名稱 視網(wǎng)膜母細胞瘤相關蛋白p130抗體
別    名 130 kDa retinoblastoma associated protein; FLJ26459; p130; PRB 2; PRB2; Rb 2; Rb2; RBL2; RBR 2; RBR2; Retinoblastoma like 2; Retinoblastoma like protein 2; Retinoblastoma Related Gene.   
研究領域 腫瘤  細胞生物  免疫學  染色質(zhì)和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Cow,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 125kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Rb2 p130: 51-150/1139 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.

Function:
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Subunit:
Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the retinoblastoma protein (RB) family.

SWISS:
Q08999

Gene ID:
5934

Database links:

Entrez Gene: 5934 Human

Entrez Gene: 19651 Mouse

Entrez Gene: 81758 Rat

Omim: 180203 Human

SwissProt: Q08999 Human

SwissProt: 235580 Mouse



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