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Rabbit Anti-EMR2  antibody (bs-13634R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-13634R
英文名稱 Rabbit Anti-EMR2  antibody
中文名稱 CD312抗體
別    名 CD 312; CD 312 antigen; CD312; CD312 antigen; Egf like module containing mucin like hormone receptor like 2; Egf like module containing mucin like hormone receptor like sequence 2; EGF like module EMR2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; EMR2; EMR2_HUMAN.  
研究領域 細胞生物  信號轉(zhuǎn)導  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EMR2: 451-550/823 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The epidermal growth factor (EGF) family constitutes a group of class B, G protein-coupled receptors, which includes CD97 and EMR2. EMR2 is a member of the EGF-TM7 receptor subfamily. EGF-TM7 receptors are a family of class B, seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal EGF-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. EMR2 is a heptahelical molecule predominantly expressed on cells of the immune system such as leukocytes. EMR2 is proteo-lytically cleaved into two separate subunits: a seven-transmembrane subunit, and an extracellular Alpha subunit.

Function:
Receptor probably involved in cell attachment.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested.

Post-translational modifications:
modificationsAutoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 5 EGF-like domains.
Contains 1 GPS domain.

SWISS:
Q9UHX3

Gene ID:
30817

Database links:

Entrez Gene: 30817 Human

Omim: 606100 Human

SwissProt: Q9UHX3 Human

Unigene: 531619 Human



產(chǎn)品圖片
Sample: TM4(Mouse) Cell Lysate at 30 ug MCF-7(Human) Cell Lysate at 30 ug Primary: Anti-EMR2 (bs-13634R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 88 kD Observed band size: 128 kD
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