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Rabbit Anti-CECR2  antibody (bs-13824R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-13824R
英文名稱 Rabbit Anti-CECR2  antibody
中文名稱 貓眼綜合征染色體候選基因2抗體
別    名 Cat eye syndrome chromosome region candidate 2; CECR2_HUMAN; KIAA1740.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)菌及病毒  結(jié)合蛋白  細(xì)胞表面分子  淋巴細(xì)胞  t-淋巴細(xì)胞  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CECR2: 201-300/1484 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. This family consists of several mammalian T-cell surface antigen CD2 proteins as well as homologous African swine fever virus sequences.

Function:
Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis.

Subunit:
Part of the CECR2-containing remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with acetylated lysine residues on histone H2A and H3 (in vitro). Interacts with LRPPRC.

Tissue Specificity:
Highly expressed in skeletal muscle, thymus, placenta and lung. Expressed at lower level in brain, heart, colon, spleen, kidney.

Similarity:
Contains 1 bromo domain.

SWISS:
Q9BXF3

Gene ID:
27443

Database links:

Entrez Gene: 27443 Human

Omim: 607576 Human

SwissProt: Q9BXF3 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CECR2) Polyclonal Antibody, Unconjugated (bs-13824R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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