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Rabbit Anti-DERL3  antibody (bs-14281R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-14281R
英文名稱 Rabbit Anti-DERL3  antibody
中文名稱 內質網退化蛋白3抗體
別    名 C22orf14; Degradation in endoplasmic reticulum protein 3; DER 3; Der1 like domain family member 3; Der1 like protein 3; Der1-like protein 3; DER3; DERL 3; DERL3_HUMAN; Derlin 3; Derlin 3 protein; Derlin-3; Derlin3; DERtrin 3; DERtrin-3; DERtrin3; IZP 6; IZP6; LLN 2; LLN2; MGC71803.  
Specific References  (2)     |     bs-14281R has been referenced in 2 publications.
[IF=4.493] Qin Wentao. et al. Systematic Construction and Validation of a Novel Ferroptosis-Related Gene Model for Predicting Prognosis in Cervical Cancer. J IMMUNOL RES. 2022;2022:2148215  IHC ;  Human.  
[IF=3.368] Manman Geng. et al. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. Clin Immunol. 2020 Nov;220:108579  IHC ;  Rat.  
研究領域 信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DERL3: 51-150/235 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Function:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.

Similarity:
Belongs to the derlin family.

SWISS:
Q96Q80

Gene ID:
91319

Database links:

Entrez Gene: 91319 Human

Entrez Gene: 614334 Cow

Entrez Gene: 70377 Mouse

Omim: 610305 Human

SwissProt: Q0P5E4 Cow

SwissProt: Q96Q80 Human

SwissProt: Q9D8K3 Mouse

Unigene: 593679 Human

Unigene: 275878 Mouse



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