| 產(chǎn)品編號 | bs-14486R |
| 英文名稱 | Rabbit Anti-ECM29 antibody |
| 中文名稱 | ECM29蛋白抗體 |
| 別 名 | ECM29 homolog, proteasome accessory protein; FLJ22036; ECM29_HUMAN; KIAA0368; KIAA1962; Proteasome associated protein ECM29 homolog; RP11-386D8.2. |
| 研究領(lǐng)域 | 細(xì)胞生物 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 204kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ECM29: 1701-1845/1845 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ECM29 is a 1,845 amino acid protein containing twenty-seven HEAT repeats. Localizing primarily to endoplasmic reticulum, ECM29 acts as an adapter or scaffolding protein, binding to the 26S proteasome, motor proteins, and other compartment specific proteins. The N-terminus of ECM29 binds endocytic proteins, including rabaptin, Rab11-FIP4, and VPS11, while the C-terminus binds myosins and kinesins. ECM29 may also play a role in endoplasmic reticulum (ER)-associated protein degradation (ERAD) in addition to other enhanced proteolysis. Function: ECM29 appears to be one of three proteins which associate significantly with proteasomes. ECM29 has been shown to enhance the stability of the proteasome. ECM29 deletion has been shown to produce 26S proteasomes which dissociated in the absence of ATP. It was thus suggested that ECM29 tethers the regulatory complex to the proteasome. Subcellular Location: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm ?cytoskeleton ?centrosome. Nucleus. Similarity: Contains 27 HEAT repeats. SWISS: Q5VYK3 Gene ID: 23392 Database links: Entrez Gene: 23392 Human Entrez Gene: 230249 Mouse SwissProt: Q5VYK3 Human SwissProt: Q6PDI5 Mouse Unigene: 368255 Human |
