| 產(chǎn)品編號(hào) | bs-16381R |
| 英文名稱 | Rabbit Anti-hair cortex Cytokeratin antibody |
| 中文名稱 | 毛皮質(zhì)細(xì)胞角蛋白/細(xì)胞角蛋白40抗體 |
| 別 名 | CK-40; Cytokeratin-40; Cytokeratin40; K1C40_HUMAN; Cytokeratin 40; Keratin, type I cytoskeletal 40; Keratin-40; KRT40; Type I hair keratin Ka36. |
| 研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 48kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human hair cortex Cytokeratin: 151-250/431 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes. Function: The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. Subunit: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level). Similarity: Belongs to the intermediate filament family. SWISS: Q6A162 Gene ID: 125115 Database links: Entrez Gene: 125115 Human Entrez Gene: 406221 Mouse SwissProt: Q6A162 Human SwissProt: Q6IFX3 Mouse Unigene: 534929 Human Unigene: 422372 Mouse |
