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Rabbit Anti-KCNN1  antibody (bs-16910R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-16910R
英文名稱 Rabbit Anti-KCNN1  antibody
中文名稱 電導(dǎo)鈣激活鉀通道蛋白1抗體
別    名 hSK1; KCa2.1; KCNN 1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCA1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 60kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNN1: 401-500/543 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Subcellular Location:
Membrane.

Similarity:
Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

SWISS:
Q92952

Gene ID:
3780

Database links:

Entrez Gene: 3780 Human

Entrez Gene: 84036 Mouse

Entrez Gene: 54261 Rat

Omim: 602982 Human

SwissProt: Q92952 Human

SwissProt: Q9EQR3 Mouse

SwissProt: P70606 Rat

Unigene: 158173 Human

Unigene: 32074 Mouse

Unigene: 44422 Rat



產(chǎn)品圖片
Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-KCNN1 (bs-16910R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 60 kD
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