| 產(chǎn)品編號(hào) | bs-17192R |
| 英文名稱 | Rabbit Anti-IZUMO1 antibody |
| 中文名稱 | IZUMO1蛋白抗體 |
| 別 名 | IZUM1_HUMAN; IZUMO; Izumo sperm egg fusion 1; Izumo sperm-egg fusion protein 1; Izumo1; MGC34799; OBF; Oocyte binding/fusion factor; Sperm specific protein izumo; Sperm-specific protein izumo. |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 細(xì)胞分化 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 39kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IZUMO1: 151-250/350 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008] Function: Involved in the fertilization process. May be involved in the fusion of the sperm with the egg. Subunit: Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity). Subcellular Location: Membrane. Tissue Specificity: Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. Post-translational modifications: N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm. Phosphorylated. Similarity: Belongs to the Izumo family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: Q8IYV9 Gene ID: 284359 Database links: Entrez Gene: 284359 Human Entrez Gene: 73456 Mouse Omim: 609278 Human SwissProt: Q8IYV9 Human SwissProt: Q9D9J7 Mouse Unigene: 400688 Human Unigene: 380445 Mouse Unigene: 125416 Rat |
