| 產(chǎn)品編號 | bs-17743R |
| 英文名稱 | Rabbit Anti-MPV17L antibody |
| 中文名稱 | MPV17L蛋白抗體 |
| 別 名 | FLJ39599; M LP homolog; M LPH; MGC70356; MLPH1; MLPH2; MPV 17L; Mpv17 like protein type 1; Mpv17 like protein type 2; MPV17 mitochondrial membrane protein like; MPV17L1. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MPV17L: 101-160/196 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
MPV17L is a 196 amino acid multi-pass membrane protein belonging to the peroxisomal membrane protein PXMP2/4 family. M-LPS (also known as M-LPH1) and M-LPL (also known as M-LPH2) are alternatively spliced isoforms of MPV17L and are ubiquitously expressed in human tissues, however only M-LPS exists at the protein level and mainly resides in kidney. MPV17L may be involved in protecting against mitochondrial oxidative stress and apoptosis, and participates in reactive oxygen species (ROS) metabolism by up- or down-regulating genes of antioxidant enzymes. MPV17L may play a role in the development of early-onset glomerulosclerosis, which is the hardening or formation of scar tissue of the glomerulus in the kidney. The gene encoding MPV17L maps to human chromosome 16p13.11. Function: MPV17L Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes. Subcellular Location: Isoform 1: Peroxisome membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle. Similarity: Belongs to the peroxisomal membrane protein PXMP2/4 family. SWISS: Q2QL34 Gene ID: 255027 Database links: Entrez Gene: 255027 Human SwissProt: Q2QL34 Human |
