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Rabbit Anti-LEPROTL1  antibody (bs-18234R)  
訂購(gòu)熱線:400-901-9800
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說(shuō)明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-18234R
英文名稱 Rabbit Anti-LEPROTL1  antibody
中文名稱 瘦素受體重疊轉(zhuǎn)錄基因1抗體
別    名 HSPC112; Leprotl1; Leptin receptor overlapping transcript-like 1; LERL1_HUMAN; my047; Vps55.  
研究領(lǐng)域 細(xì)胞生物  生長(zhǎng)因子和激素  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Zebrafish,Dog,GuineaPig,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 14kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LEPROTL1: 81-131/131 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Mutation of Ob (Obesity factor), also known as leptin precursor, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. LEPROTL1 (Leptin receptor overlapping transcript-like 1) is a 131 amino acid multi-pass membrane protein that is highly homologous to the leptin receptor gene-related protein, Ob-R. LEPROTL1 is widely expressed and contains a JAK binding site. The LEPROTL1 gene is located on chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes.

Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Subcellular Location:
Membrane.

Tissue Specificity:
Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Similarity:
Belongs to the OB-RGRP/VPS55 family.

SWISS:
O95214

Gene ID:
23484

Database links:

Entrez Gene: 23484 Human

Entrez Gene: 68192 Mouse

Entrez Gene: 361160 Rat

Omim: 607338 Human

SwissProt: O95214 Human

SwissProt: Q9CQ74 Mouse

Unigene: 146585 Human



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