| 產(chǎn)品編號 | bs-19190R |
| 英文名稱 | Rabbit Anti-NEDL2 antibody |
| 中文名稱 | E3泛素蛋白連接酶HECW2抗體 |
| 別 名 | C2 and WW domain-containing protein 2; E3 ubiquitin protein ligase HECW2; E3 ubiquitin-protein ligase HECW2; HECT; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; Hecw2; HECW2_HUMAN; KIAA130; KIAA1301; NEDD4 like E3 ubiquitin protein ligase 2; NEDD4 Related E3 Ubiquitin Ligase; NEDD4-like E3 ubiquitin-protein ligase 2. |
| 研究領(lǐng)域 | 細(xì)胞生物 表觀遺傳學(xué) 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 176kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEDL2: 21-120/1572 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NEDL2 is a 1,572 amino acid cytoplasmic protein that is involved in protein modification and ubiquitination and exists as two alternatively spliced isoforms. NEDL2 acts as an E3 ubiquitin-protein ligase that enhances p73 transcription activation, ubiquitination and stabilization, and is highly expressed in adult heart, lung and brain. Containing one C2 domain, two WW domains and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain, NEDL2 is encoded by a gene that maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in adult brain, lung and heart. Similarity: Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 2 WW domains. SWISS: Q9P2P5 Gene ID: 57520 Database links: Entrez Gene: 57520 Human Entrez Gene: 329152 Mouse SwissProt: Q9P2P5 Human SwissProt: Q6I6G8 Mouse Unigene: 654742 Human Unigene: 132150 Mouse Unigene: 447527 Mouse Unigene: 198842 Rat |
