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Rabbit Anti-Relaxin 2  antibody (bs-19835R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-19835R
英文名稱 Rabbit Anti-Relaxin 2  antibody
中文名稱 松弛肽2/松弛素2抗體
別    名 H2; H2-preprorelaxin; H2-RLX; Prorelaxin H2; REL2_HUMAN; Relaxin 2 (H2); Relaxin 2; Relaxin A chain; Relaxin H2; Relaxin, Ovarian, Of Pregnancy; RLN2; RLXH2.  
研究領域 細胞生物  信號轉導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21kDa
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Relaxin 2: 101-185/185 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

Function:
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Subcellular Location:
Secreted.

Tissue Specificity:
Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary.

Similarity:
Belongs to the insulin family.

SWISS:
P04808

Gene ID:
6013

Database links:

Entrez Gene: 6013 Human

Entrez Gene: 6019 Human

Entrez Gene: 25616 Rat

Omim: 179740 Human

SwissProt: P04090 Human

SwissProt: P04808 Human

SwissProt: P47932 Mouse

SwissProt: P01347 Rat

Unigene: 127032 Human

Unigene: 368996 Human

Unigene: 5033 Mouse

Unigene: 9830 Rat



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